نتایج جستجو برای: 1β/α

تعداد نتایج: 1  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Carolina Muscoli Tim Doyle Concetta Dagostino Leesa Bryant Zhoumou Chen Linda R Watkins Jan Ryerse Erhard Bieberich William Neumman Daniela Salvemini

The clinical efficacy of opiates for pain control is severely limited by analgesic tolerance and hyperalgesia. Herein we show that chronic morphine upregulates both the sphingolipid ceramide in spinal astrocytes and microglia, but not neurons, and spinal sphingosine-1-phosphate (S1P), the end-product of ceramide metabolism. Coadministering morphine with intrathecal administration of pharmacolog...

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