* Building 56, Cranfield University, Wharley End, Cranfield, Bedfordshire, MK43 0AL, UK. Tel: +44 (0)1234 750111 ext: 2513; E-mail: [email protected] a Building 56, Cranfield University, Wharley End, Cranfield, Bedfordshire, MK43 0AL, UK. Fax: +44 (0)1234 751346; Tel: +44 (0)1234 750111 ext: 2379; E-mail: [email protected] b Building 61, Cranfield University, Wharley End, Cranfield...

Nitidine chloride (NC), a quaternary ammonium alkaloid, has numerous pharmacological effects, such as anticancer activity. However, it was found that NC also has hepatocellular toxicity. Because organic cation transporters 1 and 3 (OCT1 and OCT3) might mediate the influx of NC into hepatocytes, multidrug and toxin extrusion 1 (MATE1) probably mediates the efflux of NC from hepatocytes, while cy...

BACKGROUND Physicians have differing motives for using the Internet and Internet-related services in their professional work. These motives may affect their evaluation of patients who bring with them health-related information from the Internet. Differing motives may also affect physician-patient communication and subsequent prescribing behavior. OBJECTIVES to segment physicians into types ba...

Abstract 52-year-old Indian builder initially presented to his General Practitioner with exertional breathlessness but no angina. His medical history included previous tuberculosis infection, Type 2 Diabetes Mellitus and hypothyroidism. He was referred the cardiologist exclude coronary artery disease. Stress testing found T-wave inversion in inferior electrocardiogram leads transthoracic echoca...

7 Article history: 8 Received 5 September 2007 9 Received in revised form 19 March 2010 10 Accepted 31 May 2010 11 Available online xxxx 1234 15