background: the seladin-1 (selective alzheimer disease indicator-1), also known as dhcr24, is a gene found to be down-regulated in brain region affected by alzheimer disease (ad). whereas, hair follicle stem cells (hfsc), which are affected in with neurogenic potential, it might to hypothesize that this multipotent cell compartment is the predominant source of seladin-1. our aim was to evaluate...

Background: The seladin-1 (selective Alzheimer disease indicator-1), also known as DHCR24, is a gene found to be down-regulated in brain region affected by Alzheimer disease (AD). Whereas, hair follicle stem cells (HFSC), which are affected in with neurogenic potential, it might to hypothesize that this multipotent cell compartment is the predominant source of seladin-1. Our aim was to evaluate...

BACKGROUND The seladin-1 (selective Alzheimer disease indicator-1), also known as DHCR24, is a gene found to be down-regulated in brain region affected by Alzheimer disease (AD). Whereas, hair follicle stem cells (HFSC), which are affected in with neurogenic potential, it might to hypothesize that this multipotent cell compartment is the predominant source of seladin-1. Our aim was to evaluate ...

patients with type 1 diabetes mellitus have a high prevalence of coeliac disease, symptoms of which are often mild, atypical, or absent. untreated coeliac disease is associated with an increased risk of malignancy, particularly of lymphoma. therefore, we report a 9-year-old girl with coeliac disease, diabetes type 1 and selective iga deficiency. a 9-year-old female patient presented in august 2...

Abstract Alzheimer’s disease (AD) is the most common cause of dementia in elderly people. The prevalence of Alzheimer diseases is increasing in the world due to population aging. Metabolic disease such as diabetes and obesity play important role in Alzheimer disease. Hyperglycemia can play important role in brain damage. It causes cognitive impairments, functional and structural alterations in...

Selective Alzheimer's Disease Indicator-1 (Seladin-1) was originally identified by its down-regulation in the brains of Alzheimer's disease (AD) patients. Here, we re-examine existing data and present new gene expression data that refutes its role as a selective AD indicator. Furthermore, we caution against the use of the name "Seladin-1" and instead recommend adoption of the approved nomenclat...

background: recent studies have shown that oxidative stress (os) is the most important indicator in the pathogenesis of alzheimer's disease (ad), but the results in previous studies are conflicting. this study aimed to assess the plasma levels of 8-hydroxy-2'-deoxyguanosine (8-ohdg) as dna oxidative damage marker and total antioxidant capacity (tac) in patients with ad versus control ...

Introduction: Previous studies have shown that exercise enhances cognitive and functional capacities in patients with Alzheimer's disease (AD). In this study, we investigated the effect of long-term (60 days) and short- term (10 days) exercise on the spatial memory deficits in an animal model of AD. Methods: Fifty male rats were divided into 5 groups 1) intact, 2) sham, 3) sham-Alzheimer 4) ...

introduction: olibanum improves memory in different models of learning. however, the effect of olibanum on models of alzheimer’s disease has been less studied. in the present study, the effect of olibanum on memory in normal rats and in a rat model of alzheimer disease induced by intracerebroventricular injections of streptozotocin was evaluated. methods: rats received an aqueous extract of oli...