BACKGROUND C-type lectin-like molecule-1 is a transmembrane receptor expressed on myeloid cells, acute myeloid leukemia blasts and leukemic stem cells. To validate the potential of this receptor as a therapeutic target in acute myeloid leukemia, we generated a series of monoclonal antibodies against the extracellular domain of C-type lectin-like molecule-1 and used them to extend the expression...

Serum protein electrophoresis (SPE) is the hub of laboratory testing for monoclonal gammopathies and is a component of almost all diagnostic panels (1–3 ). The sensitivity of SPE as a screening test, however, is dependent on how SPE abnormalities are defined (4 ). Discrete, quantifiable electrophoretic bands (M-spikes) are almost always monoclonal proteins. Subtle abnormalities such as fuzzy ba...

Considering the different clinical symptoms of leishmaniasis in Iran, and the wide distribution of its agent and the little information in this regard, this study was performed to characterize the responsible variants using monoclonal antibodies. A total of 156 isolates of Leishmania from patients with cutaneous leishmaniasis and one isolate from rat were characterized using the standard monoc...