Introduction: Binding a monoclonal antibody to tumor associated antigens is an effective method for cancer therapy because these agents can specifically target malignant cells, in fact monoclonal antibodies are effective agents for diagnosis, grading and treatment of different kinds of cancers. Methods: In this research, a new monoclonal antibody against colon cancer cells was prepared an...

a survey was carried out in five provinces of iran (kerman, sistan and baluchestan, hormozgan, khorasan and yazd) for the presence of alfalfa mosaic virus (amv) sero-types in alfalfa during 2002 to 2003. the number of samples collected was 250, represent-ing the diversity and geographical distribution of amv in these areas. diagnosis was car-ried out using polyclonal (pabs) and monoclonal (mabs...

background: the humbug gene is a truncated isoform of aspartyl β-hydroxylase (asph) gene that is overexpressed in many human malignancies. in recent years, since humbug has received increasing attention, it is considered as a potential therapeutic molecular target. therefore, it is necessary for preparing humbug protein and its monoclonal antibody to investigate its structure and function. meth...

Cancer immunotherapy has gained a lot of interest over the past few years due to the success of immune checkpoint inhibitors in treating cancer (1, 2). Immune checkpoint inhibitors, such as monoclonal antibodies against cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), have been shown to increase survival of patients with advanced cancers (1, 2). These in...

introduction: as monoclonal antibodies are potential tools for characterization of soluble or cellular surface antigens, use of these proteins has always been considered in infertility and reproduction research. therefore, in this study, monoclonal antibodies against human sperm surface antigens were produced. material and methods: to produce specific clones against human sperm surface antigens...