نتایج جستجو برای: 1 perforin proviral load

تعداد نتایج: 2872665  

2013
Nicolas A. Gillet Lucy Cook Daniel J. Laydon Carol Hlela Kristien Verdonck Carolina Alvarez Eduardo Gotuzzo Daniel Clark Lourdes Farré Achiléa Bittencourt Becca Asquith Graham P. Taylor Charles R. M. Bangham

Human T-lymphotropic Virus-1 (HTLV-1) is a retrovirus that persists lifelong by driving clonal proliferation of infected T-cells. HTLV-1 causes a neuroinflammatory disease and adult T-cell leukemia/lymphoma. Strongyloidiasis, a gastrointestinal infection by the helminth Strongyloides stercoralis, and Infective Dermatitis associated with HTLV-1 (IDH), appear to be risk factors for the developmen...

Journal: :Journal of Immune Based Therapies and Vaccines 2008
Anna A Herasimtschuk Samantha J Westrop Graeme J Moyle Jocelyn S Downey Nesrina Imami

BACKGROUND Efficacious immune-based therapy in treated chronic HIV-1 infection requires the induction of virus-specific CD4+ T cells and subsequent maturation and maintenance of specific memory CD8+ T cells. Concomitant daily administration of recombinant human growth hormone (rhGH) with highly active antiretroviral therapy (HAART) was used in chronically infected patients with lipodystrophy in...

2011
Emanuele Nicastri Chiara Tommasi Isabella Abbate Stefano Bonora Massimo Tempestilli Rita Bellagamba Magdalena Viscione Gabriella Rozera Anna L Gallo Jelena Ivanovic Alessandra Amendola Leopoldo Pucillo Giovanni Di Perri Maria R Capobianchi Pasquale Narciso

Background: Raltegravir is the first approved antiretroviral able to prevent HIV genome integration into the host chromosomes. The aim of the study is to test if raltegravir plasma concentrations can be associated with proviral DNA decline during raltegravir-based salvage therapy. Methods: A total of 33 multidrug-resistant HIV-infected patients were enrolled in a longitudinal open-label pilot s...

Journal: :Journal of immunology 1999
M J Smyth K Y Thia E Cretney J M Kelly M B Snook C A Forbes A A Scalzo

We provide the first demonstration, using experimental and spontaneous models of metastasis in C57BL/6 (B6) (RM-1 prostate carcinoma) and BALB/c (DA3 mammary carcinoma) mice, that tumor metastasis is primarily controlled by perforin-dependent cytotoxicity mediated by NK1.1+ cells. MHC class Ilow RM-1 and DA3 tumor cells were sensitive in vitro to Fas-mediated lysis or spleen NK cells in a perfo...

2014
Camila F. Amorim Anselmo S. Souza Angela G. Diniz Natália B. Carvalho Silvane B. Santos Edgar M. Carvalho

The Human T lymphotropic virus type-1 (HTLV-1) infects predominantly T cells, inducing proliferation and lymphocyte activation. Additionally, HTLV-1 infected subjects are more susceptible to other infections caused by other intracellular agents. Monocytes/macrophages are important cells in the defense against intracellular pathogens. Our aims were to determine the frequency of monocytes subsets...

Journal: :Journal of virology 2003
Atsuhiko Hasegawa Takashi Ohashi Shino Hanabuchi Hirotomo Kato Fumiyo Takemura Takao Masuda Mari Kannagi

Adult T-cell leukemia (ATL) occurs in a small population of human T-cell leukemia virus type 1 (HTLV-1)-infected individuals. Although the critical risk factor for ATL development is not clear, it has been noted that ATL is incidentally associated with mother-to-child infection, elevated proviral loads, and weakness in HTLV-1-specific T-cell immune responses. In the present study, using a rat s...

2015
Ryan M McCormack Kirill Lyapichev Melissa L Olsson Eckhard R Podack George P Munson

Perforin-2 (MPEG1) is an effector of the innate immune system that limits the proliferation and spread of medically relevant Gram-negative, -positive, and acid fast bacteria. We show here that a cullin-RING E3 ubiquitin ligase (CRL) complex containing cullin-1 and βTrCP monoubiquitylates Perforin-2 in response to pathogen associated molecular patterns such as LPS. Ubiquitylation triggers a rapi...

Journal: :The Journal of Experimental Medicine 1997
David Kägi Bernhard Odermatt Peter Seiler Rolf M. Zinkernagel Tak W. Mak Hans Hengartner

To investigate the role of T cell-mediated, perforin-dependent cytotoxicity in autoimmune diabetes, perforin-deficient mice were backcrossed with the nonobese diabetes mouse strain. It was found that the incidence of spontaneous diabetes over a 1 yr period was reduced from 77% in perforin +/+ control to 16% in perforin-deficient mice. Also, the disease onset was markedly delayed (median onset o...

Journal: :Blood 1990
A Gessain F Saal O Gout M T Daniel G Flandrin G de The J Peries F Sigaux

Human T-cell lymphotropic virus type I (HTLV-I) proviral integration status was examined by Southern blot analysis in peripheral blood mononuclear cell (PBMC) DNA from patients presenting a tropical spastic paraparesis (TSP) and serological evidence of HTLV-I infection. Surface phenotype and morphological aspects of PBMC were also studied. A polyclonal HTLV-I proviral integration was found in t...

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