نتایج جستجو برای: 1 perforin proviral load

تعداد نتایج: 2872665  

Journal: :Biomedical and environmental sciences : BES 2016
Qian Qian Yin Zhen Peng Li Hai Zhao Dong Pan Yan Wang Wei Si Xu Hui Xing Yi Feng Shi Bo Jiang Yi Ming Shao Li Ying Ma

OBJECTIVE To investigate distinctive features in drug-resistant mutations (DRMs) and interpretations for reverse transcriptase inhibitors (RTIs) between proviral DNA and paired viral RNA in HIV-1-infected patients. METHODS Forty-three HIV-1-infected individuals receiving first-line antiretroviral therapy were recruited to participate in a multicenter AIDS Cohort Study in Anhui and Henan Provi...

Journal: :journal of paramedical sciences 0
jahangir mohammadzade proteomics research center, faculty of para medical sciences, shahid beheshti university of medical sciences, tehran houshang amirrasouli proteomics research center, faculty of para medical sciences, shahid beheshti university of medical sciences, tehran mohammad esmaeil akbari cancer research center, shohada hospital, shahid beheshti university of medical sciences, tehran babak javanmard cancer research center, shohada hospital, shahid beheshti university of medical sciences, tehran faranak kazerouni proteomics research center, faculty of para medical sciences, shahid beheshti university of medical sciences, tehran saeed namaki proteomics research center, faculty of para medical sciences, shahid beheshti university of medical sciences, tehran

perforin(p) is the primary mediator of short term cytotoxicity, it is accumulated in response to proinflammatory  cytokines and stored in t lymphocyte , nk cells and nkt cells are released upon activation. perforin is a prototypical cytotoxic molecule involved in cell mediated immunity against various pathogens , alloantigens and particularly different tumors.the purpose of this study was to de...

Journal: :The Journal of Experimental Medicine 1989
L H Young L S Klavinskis M B Oldstone J D Young

CTL and NK cells cultured in vitro have been shown to contain a cytolytic pore-forming protein (PFP/perforin/cytolysin). To date, it has not been determined whether perforin is expressed by CTL that have been primed in vivo. Here, we have infected mice with two strains of lymphocytic choriomeningitis virus (LCMV), one of which mainly produces choriomeningitis and, the other, hepatitis. Brain an...

Journal: :Journal of virology 2016
Amanda R Panfil Nathan J Dissinger Cory M Howard Brandon M Murphy Kristina Landes Soledad A Fernandez Patrick L Green

UNLABELLED Human T-cell leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) are highly related retroviruses that transform T cells in vitro but have distinct pathological outcomes in vivo. HTLV-1 encodes a protein from the antisense strand of its proviral genome, the HTLV-1 basic leucine zipper factor (HBZ), which inhibits Tax-1-mediated viral transcription and promotes cell proliferation, a hig...

2013
Anat Melamed Daniel J. Laydon Nicolas A. Gillet Yuetsu Tanaka Graham P. Taylor Charles R. M. Bangham

The regulation of proviral latency is a central problem in retrovirology. We postulate that the genomic integration site of human T lymphotropic virus type 1 (HTLV-1) determines the pattern of expression of the provirus, which in turn determines the abundance and pathogenic potential of infected T cell clones in vivo. We recently developed a high-throughput method for the genome-wide amplificat...

2016
Hiroshi Kotani Koji Sudo Naoki Hasegawa Hiroshi Fujiwara Tomohisa Hayakawa Osamu Iketani Masaya Yamaguchi Mayumi Mochizuki Satoshi Iwata Shingo Kato

BACKGROUND The coreceptor tropism testing should be conducted prior to commencing a regimen containing a CCR5 antagonist for treatment of HIV-1 infection. For aviremic patients on long antiretroviral therapy, proviral DNA is often used instead of viral RNA in genotypic tropism testing. However, the tropism predictions from RNA and DNA are sometimes different. We examined the cause of the discre...

2003

In order to elucidate the role of the cytolytic action mediated by perforin in the course of rheumatoid arthritis (RA), the authors studied the immunophenotypic characteristics of lymphocytes containing perforin in peripheral blood (systemic level), in synovial fluid (SF), and in the synovial membrane (local level) in patients during the acute or chronic phase of RA. Cells from patients with os...

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