نتایج جستجو برای: 1 perforin proviral load

تعداد نتایج: 2872665  

2017
M. Ruiz-Riol D. Berdnik A. Llano B. Mothe C. Gálvez S. Pérez-Álvarez B. Oriol-Tordera A. Olvera S. Silva-Arrieta M. Meulbroek F. Pujol J. Coll J. Martinez-Picado C. Ganoza J. Sanchez G. Gómez T. Wyss-Coray C. Brander

Intact and broad immune cell effector functions and specific individual cytokines have been linked to HIV disease outcome, but their relative contribution to HIV control remains unclear. We asked whether the proteome of secreted cytokines and signaling factors in peripheral blood can be used to discover specific pathways critical for host viral control. A custom glass-based microarray, able to ...

2016
Christian K. Miller Kristiina M. Huttunen William A. Denny Jagdish K. Jaiswal Annette Ciccone Kylie A. Browne Joseph A. Trapani Julie A. Spicer

Evolution from a furan-containing high-throughput screen (HTS) hit (1) resulted in isobenzofuran-1(3H)-one (2) as a potent inhibitor of the function of both isolated perforin protein and perforin delivered in situ by intact KHYG-1 NK cells. In the current study, structure-activity relationship (SAR) development towards a novel series of diarylthiophene analogues has continued through the use of...

Journal: :Journal of immunology 2004
Barbara L Shacklett Catherine A Cox Máire F Quigley Christophe Kreis Neil H Stollman Mark A Jacobson Jan Andersson Johan K Sandberg Douglas F Nixon

Because GALT is a major portal of entry for HIV-1 and reservoir for viral replication, we hypothesized that an ineffective cellular immune response in intestinal mucosa might partially explain the failure of immune control in AIDS. In this study, we demonstrate that the vast majority of CD8+ T cells in rectal tissue, including HIV-1-specific cells, fail to express the cytolytic protein, perfori...

Ali Naderi Behnaz Andashti Ebrahim Mohammadi, Hamid Galehdari Mohammad Ali Molavi

Perforin gene (PRF1) mutations have been reported in 20-30% of patients with familial hemophagocytic lymphohistiocytosis (FHL), an immune disorder of infancy and early childhood. Cytotoxic T and natural killer (NK) cell activities are remarkably reduced or ab-sent in FHL patients. We report the first cases of familial hemophagocytic lymphohistiocy-tosis in an Iranian family with two siblings. E...

2012
Samantha J. McDonnel Ellen E. Sparger Paul A. Luciw Brian G. Murphy

Feline immunodeficiency virus (FIV), the lentivirus of domestic cats responsible for feline AIDS, establishes a latent infection in peripheral blood CD4+ T-cells approximately eight months after experimental inoculation. In this study, cats experimentally infected with the FIV-C strain in the asymptomatic phase demonstrated an estimated viral load of 1 infected cell per approximately 10(3) CD4+...

Journal: :Parasite 2010
M M Ibrahim M F M Soliman

Factors affecting prevalence and site preferences of heterophyid metacercariae (MC) were investigated in this study. A total of 173 specimens of a freshwater fish, Tilapia zilli were collected during autumn 2008, winter 2009 and summer 2009, from Ismailia fresh water canal, Egypt. Results showed that the total prevalence of heterophyid MC was 95.37%. The heterophyid MC consisted of Haplorchis y...

Journal: :Journal of immunology 2000
M E Rottenberg A Gigliotti Rothfuchs D Gigliotti M Ceausu C Une V Levitsky H Wigzell

By using mice genomically lacking IFN-gammaR, IL-12, perforin, and recombination-activating gene-1 (RAG-1), we analyzed the regulation and importance of IFN-gamma in the control of infection with Chlamydia pneumoniae. IL-12 participates in resistance of mice to C. pneumoniae, probably by regulating the protective levels of IFN-gamma mRNA. In turn, IFN-gamma is necessary for the increased IL-12p...

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