نتایج جستجو برای: 1 perforin proviral load

تعداد نتایج: 2872665  

Journal: :iranian journal of basic medical sciences 0
mahdi taghaddosi htlv-i foundation, ghaem hospital, mashhad university of medical sciences, mashhad, iran s. a. rahim rezaee immunology research centre, faculty of medicine, mashhad university of medical sciences, mashhad, iran houshang rafatpanah inflammation and inflammatory disease research centre, faculty of medicine ,mashhad university of medical sciences, mashhad, iran taraneh rajaei inflammation and inflammatory disease research centre, faculty of medicine ,mashhad university of medical sciences, mashhad, iran reza farid hosseini allergy research centre, school of medicine, mashhad university of medical sciences, mashhad, iran valizadeh narges immunology research centre, faculty of medicine, mashhad university of medical sciences, mashhad, iran 3 inflammation and inflammatory disease research centre, faculty of medicine ,mashhad university of medical sciences, mashhad, iran

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Journal: :Journal of medical virology 2011
Maria Fernanda Rios Grassi Viviana Nilla Olavarria Ramon de Almeida Kruschewsky Rita Elizabeth Mascarenhas Inês Dourado Luis C L Correia Carlos Maurício de Castro-Costa Bernardo Galvão-Castro

A high human T-cell lymphotropic virus type 1 (HTLV-1) proviral load is described in HTLV-1-associated diseases, especially HAM/TSP. However, the cut-off value to define high levels of HTLV-1 proviral load is not well established. 281 HTLV-1-infected patients from the HTLV reference center in Salvador, Brazil, were followed from 2005 to 2008. Patients were classified as asymptomatic, possible-,...

Journal: :Journal of clinical microbiology 2001
N Désiré A Dehée V Schneider C Jacomet C Goujon P M Girard W Rozenbaum J C Nicolas

Proviral human immunodeficiency virus type 1 (HIV-1) DNA could be a useful marker for exploring viral reservoirs and monitoring antiretroviral treatment, particularly when HIV-1 RNA is undetectable in plasma. A new technique was developed to quantify proviral HIV-1 using a TaqMan real-time PCR assay. One copy of proviral HIV-1 DNA could be detected with 100% sensitivity for five copies and the ...

Journal: :BMC Infectious Diseases 2005
Benoît Kabamba-Mukadi Philippe Henrivaux Jean Ruelle Nicole Delferrière Monique Bodéus Patrick Goubau

BACKGROUND The human immunodeficiency virus type 1 (HIV-1) proviral DNA persists in infected cells, even after prolonged successful HAART. In the present study, a relative quantification assay of HIV-1 proviral DNA by LightCycler real-time PCR based on SYBR Green I detection was developed in comparison to the number of purified CD4+ cells as estimated by the quantification of the beta-globin ge...

Journal: :Blood 2003
Ryuji Kubota Yoshitaka Furukawa Shuji Izumo Koichiro Usuku Mitsuhiro Osame

Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an inflammatory neurologic disease caused by HTLV-1 infection, in which HTLV-1-infected CD4(+) T cells and HTLV-1-specific CD8(+) T cells may play a role in the disease pathogenesis. Patients with HAM/TSP have high proviral loads despite vigorous virus-specific CD8(+) T-cell responses; how...

2014
Atefeh Yari Seyyed Abdolrahim Rezaee Narges Valizadeh Taraneh Rajaee Seyyed Mohammad Jazayeri Mojdeh Soltani Mehdi Norouzi

OBJECTIVES HTLV-1 is the first human retrovirus that has been recognized and is associated with HAM/TSP and ATLL. Studies have shown that less than five percent of HTLV-1 infected carriers develop HAM/TSP or ATLL and about ninety-five percent remain asymptomatic. Therefore, the proviral load with Tax may affect cellular genes such as cytokines and oncogenes, as well as involve in pathogenicity....

Journal: :Revista da Sociedade Brasileira de Medicina Tropical 2006
Bruna Pedroso Tamegão-Lopes Priscila Rocha Rezende Luciana Maria Cunha Maradei-Pereira José Alexandre Rodrigues de Lemos

When the human T cell lymphotropic virus (HTLV) is integrated with the host cell genome (provirus), its proviral DNA is a replication marker. Proviral load appears to be an important factor in the development of diseases related to these retroviruses. In this study, a methodology for absolute quantification of the HTLV-1 and HTLV-2 proviral load using real-time PCR was developed. Fifty-three bl...

2009
Jun Yong Choi Young Goo Song Young Hwa Kim Chang Oh Kim Myung Soo Kim Bum Sik Chin Sang Hoon Han Suk Hoon Choi Han Sung Lee Su Jin Jeong Heekyoung Choi June Myung Kim

To evaluate factors associated with human immunodeficiency virus type 1 (HIV-1) proviral DNA load, we conducted a cross-sectional study of 36 chronically HIV-1-infected individuals with undetectable plasma viral RNA. We used real-time polymerase chain reaction to determine the number of HIV-1 proviral DNA copies per 10(6) peripheral blood mononuclear cells. The mean level of plasma viral RNA wh...

Journal: :Journal of immunology 2009
Tarek Kattan Aidan MacNamara Aileen G Rowan Hirohisa Nose Angelina J Mosley Yuetsu Tanaka Graham P Taylor Becca Asquith Charles R M Bangham

In human T-lymphotropic virus type 1 (HTLV-1) infection, a high frequency of HTLV-1-specific CTLs can co-exist stably with a high proviral load and the proviral load is strongly correlated with the risk of HTLV-1-associated inflammatory diseases. These observations led to the hypothesis that HTLV-1 specific CTLs are ineffective in controlling HTLV-1 replication but contribute to the pathogenesi...

Journal: :The Journal of antimicrobial chemotherapy 2012
Ana Treviño Patricia Parra Tamara Bar-Magen Carolina Garrido Carmen de Mendoza Vincent Soriano

BACKGROUND In vitro studies support that integrase inhibitors, such as raltegravir, may inhibit human T cell lymphotropic virus type 1 (HTLV-1) replication. However, this hypothesis has not been tested in vivo. METHODS HTLV-1-infected individuals were invited to participate in a pilot, open study that examined whether 400 mg of raltegravir twice daily could exhibit any recognizable virologica...

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