نتایج جستجو برای: 1 perforin proviral load

تعداد نتایج: 2872665  

2013
Carlos Javier Panei Shin-nosuke Takeshima Takashi Omori Tetsuo Nunoya William C Davis Hiroshi Ishizaki Kazuhiro Matoba Yoko Aida

BACKGROUND Bovine leukemia virus (BLV) is associated with enzootic bovine leukosis (EBL), which is the most common neoplastic disease of cattle. BLV infection may remain clinically silent at the aleukemic (AL) stage, cause persistent lymphocytosis (PL), or, more rarely, B cell lymphoma. BLV has been identified in B cells, CD2+ T cells, CD3+ T cells, CD4+ T cells, CD8+ T cells, γ/δ T cells, mono...

2013
Jordana Grazziela Alves Coelho-dos-Reis Livia Passos Mariana Costa Duarte Marcelo Grossi Araújo Ana Carolina Campi-Azevedo Andréa Teixeira-Carvalho Vanessa Peruhype-Magalhães Bruno Caetano Trindade Raquel dos Santos Dias Marina Lobato Martins Anna Barbara de Freitas Carneiro-Proietti Antônio Carlos Guedes Denise Utsch Gonçalves Olindo Assis Martins-Filho

In the present study, the frequency, the activation and the cytokine and chemokine profile of HTLV-1 carriers with or without dermatological lesions were thoroughly described and compared. The results indicated that HTLV-1-infected patients with dermatological lesions have distinct frequency and activation status when compared to asymptomatic carriers. Alterations in the CD4(+)HLA-DR(+), CD8(+)...

Journal: :The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 2012
Viviana Nilla Olavarria Alline do Nascimento Gomes Ramon de Almeida Kruschewsky Bernardo Galvão-Castro Maria Fernanda Rios Grassi

INTRODUCTION Variations in human T cell lymphotropic virus type 1 (HTLV-1) proviral load (PVL) in infected individuals over time are not well understood. OBJECTIVE To evaluate the evolution of proviral load in asymptomatic individuals and HAM/TSP patients in order to help determine periodicity for measuring proviral load. METHODS A group of 104 HTLV-1 infected patients, followed at the HTLV...

Journal: :Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2010
Maria de Fátima Paim de Oliveira Maria das Graças Vieira Janeusa Primo Isadora C Siqueira Edgar M Carvalho Lourdes Farré Priscila Lima Fatal Achiléa L Bittencourt

BACKGROUND Infective dermatitis associated with HTLV-1 (IDH) is a severe childhood form of eczema that may progress to adult T-cell leukemia/lymphoma (ATL). OBJECTIVE In this study, the presence of clinical and laboratory parameters suggestive of ATL was evaluated in a cohort of 30 patients with IDH. STUDY DESIGN Over a period of 33 months, the patients were submitted to three-monthly clini...

Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Only a limited percentage of infected individuals develop disease in response to the virus while the majority remain asymptomatic and HAM/TSP is the most common clinical manifestation of the virus. HAM/TSP is an inflamma...

Journal: :Journal of clinical microbiology 2012
Shirley V Komninakis Domingos E M Santos Carlos Santos Márcia P R Oliveros Sabri Sanabani Ricardo S Diaz

The impact of Structured Treatment Interruption (STI) in peripheral blood mononuclear cell (PBMC) proviral reservoirs in 41 highly active antiretroviral therapy (HAART)-treated viremic individuals at baseline and 12 weeks after STI was determined using quantitative PCR (qPCR). Viral load increased 0.7 log(10) and CD4 decreased 97.5 cells/mm(3) after 12 weeks. A total of 28 of the 41 individuals...

2011
Xin Zheng Scott Carver Ryan M. Troyer Julie A. Terwee Sue VandeWoude

We developed a feline model of lentiviral cross-species transmission using a puma lentivirus (PLV or FIV(Pco)) which infects domestic cats but does not cause disease. Infection with PLV protects cats from CD4+ T-cell decline caused by subsequent infection with virulent feline immunodeficiency virus (FIV). Previous studies implicate innate immune and/or cellular restriction mechanisms for FIV di...

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