1. Abstract 2. Introduction 3. Materials and methods 3.1. Main reagents and cell culture 3.2. MTT assay 3.3. Comet assay 3.4. Cell cycle analysis by flow cytometry 3.5. The Caspase-3 colorimetric activity assay 3.6. Statistical analysis 4. Results 4.1. MTT assay 4.2. Comet assay 4.3. FCM assay the distribution of cell cycle and cell apoptosis 4.4. The expression of Caspase-3 5. Discussion 6. Ac...

Current researches have showed that N3, N5-diaryl-2, 6-dimethyl -1, 4-dihydropyrine-3, 5- dicarboxamide analogues demonstrate notable anti-tubercular activity. In this study, Hantzsch condensation was used to design and synthesize new analogues of dihydropyridine (DHP). Different diary carboxamides were inserted at positions 3 and 5 of the DHP ring. 4(5)-chloro-2-ethyl-5(4)-imidazolyl moiety wa...