a highly efficient and environmentally friendly synthesis of various 1,5-diaryl-3-(arylamino)-1h-pyrrol-2(5h)-ones catalyzed by 1-methylpiperidinium hydrogen sulfate via one-pot cyclo-condensation reaction ofaldehydes, amines and ethyl 2-oxopropanoate under ambient conditions has been explored. the presentmethodology offers several advantages such as good yields, simple procedure, shorter react...

A highly efficient and environmentally friendly synthesis of various 1,5-diaryl-3-(arylamino)-1H-pyrrol-2(5H)-ones catalyzed by 1-methylpiperidinium hydrogen sulfate via one-pot cyclo-condensation reaction ofaldehydes, amines and ethyl 2-oxopropanoate under ambient conditions has been explored. The presentmethodology offers several advantages such as good yields, simple procedure, shorter react...

Methyl 1-aryl-3-cinnamoyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates interact with 3-(arylamino)-1H-inden-1-ones to give the corresponding 1,1'-diaryl-3'-cinnamoyl-4'-hydroxy-1H-spiro[indeno[1,2-b]pyrrole-3,2'-pyrrole]-2,4,5'(1'H)-triones in good yields.

One pot synthesis of terpyrromethanes (3a) and [di(1H-pyrrol-2-yl)methyl]heteroarenes (3b-m) has been delineated by Amberlyst 15 catalyzed condensation of pyrrole and heterocyclic aldehydes (2), not reported earlier. The compounds 3a and 3b have been formylated to 5-[di(5-formyl-1H-pyrrol-2-yl)methyl]-1H-pyrrole-2-carbaldehyde (4a) and 5[(5-formyl-1H-pyrrol-2-yl)(3-pyridinyl)methyl]-1H-pyrrole-...

Screening identified 2-(3-((4,6-dioxo-2-thioxotetrahydropyrimidin-5(2H)-ylidene)methyl)-2,5-dimethyl-1H-pyrrol-1-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile as an MDM2-p53 inhibitor (IC50 = 12.3 μM). MDM2-p53 and MDMX-p53 activity was seen for 5-((1-(4-chlorophenyl)-2,5-diphenyl-1H-pyrrol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione (MDM2 IC50 = 0.11 μM; MDMX IC50 = 4.2...

Irradiation of 1-substituted benzotriazole arylhydrazones 3a-c, 4a,b and 5a,b with a 16 W low pressure mercury arc-lamp (254 nm) for 24 h gave phenanthridin-6-yl-2-phenyldiazines 9a-c, phenanthridin-6(5H)-ones 10a-c, 1-anilinobenzimidazoles 11a-c, 2-aryl-1H-benzimidazoles 12a-c, 1-arylamino-1H-benzimidazol-2-carboxylic acid ethyl esters 14a,b, 1-aryl-1H, 9H-benzo [4,5][1,2,3] triazolo[1,2-a]te...

In an effort to develop new potent antimicrobial and anticancer agents, new pyrrole-based chalcones were designed and synthesized via the base-catalyzed Claisen-Schmidt condensation of 2-acetyl-1-methylpyrrole with 5-(aryl)furfural derivatives. The compounds were evaluated for their in vitro antimicrobial effects on pathogenic bacteria and Candida species using microdilution and ATP luminescenc...

An efficient two-step protocol for the asymmetric synthesis of 1H-pyrrol-3(2H)-one derivatives in 99% ee from conveniently accessed 2,3-diketoesters has been developed.

The solid-state structures of a series of seven substituted 3-methylidene-1H-indol-2(3H)-one derivatives have been determined by single-crystal X-ray diffraction and are compared in detail. Six of the structures {(3Z)-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2(3H)-one, C(13)H(10)N(2)O, (2a); (3Z)-3-(2-thienylmethylidene)-1H-indol-2(3H)-one, C(13)H(9)NOS, (2b); (3E)-3-(2-furylmethylidene)-1H-indol...