The discovery of dwarf planet Eris was followed shortly by the discovery of its satellite, Dysnomia, but the satellite orbit, and thus the system mass, was not known. New observations with the Keck Observatory and the Hubble Space Telescopes show that Dysnomia has a circular orbit with a radius of 37,350 +/- 140 (1-sigma) kilometers and a 15.774 +/- 0.002 day orbital period around Eris. These o...

In designing mutagenesis experiments, it is often crucial to know how certain mutations will affect the structure and thermodynamic stability of the protein. Here, we present a methodology, Eris, to efficiently and accurately compute the stability changes of proteins upon mutations using our protein-modeling suite, Medusa. We evaluate the stability changes upon mutations for 595 mutants from fi...

The Participatory Learning Approach (PLA, pronounced “play”) engages students as active participants in the full life cycle of homework, projects, and examination. PLA’s core idea is that students design the questions or projects, execute them, and then assess and grade their peers’ solutions. Each stage can be performed by individuals or by teams. Students should be able to observe (read) ever...

Progressive supranuclear palsy and Parkinson’s disease have distinct underlying neuropathology, but both diseases affect cognitive function in addition to causing a movement disorder. They impair response inhibition and may lead to impulsivity, which can occur even in the presence of profound akinesia and rigidity. The current study examined the mechanisms of cognitive impairments underlying di...

The methodology described in this article was developed to transcend the limitations of both approaches. Its goal is to use existing data to identify small areas with high levels of adolescent childbearing. The method is an active approach to identify what can be defined as “hot spots” for adolescent births, even when they are located in counties or communities where adolescent births are not c...

The idiopathic inflammatory myopathies are a heterogeneous group of rare chronic autoimmune diseases that include polymyositis (PM) and dermatomyositis (DM). Antisynthetase syndrome (ASS) is recognized as a subset of the idiopathic inflammatory myopathies and the syndrome is characterized by myositis associated with interstitial lung disease (ILD) and autoantibodies against aminoacyl-tRNA synth...

Fish oil contains large amounts of essential omega-3 fatty acids, such as eicosapentaenoic and docosahexaneoic acids, which are building structures of cell membranes. The goal of this study was to elucidate the effects of dietary omega-3 fatty acid supplementation on the oxidant/antioxidant status of erythrocytes in rats. The malondialdehyde (MDA) and nitric oxide (NO) levels and the catalase (...

The directional flow of information in neurons depends on compartmentalization: dendrites receive inputs whereas axons transmit them. Axons and dendrites likewise contain structurally and functionally distinct subcompartments. Axon/dendrite compartmentalization can be attributed to neuronal polarization, but the developmental origin of subcompartments in axons and dendrites is less well underst...