Winter cover crops have the potential to increase soil organic C in the corn (Zea mays L.)–soybean [Glycine max (L.) Merr.] rotation in the upper Midwest. Management effects on soil C, however, are often difficult to measure because of the spatial variation of soil C across the landscape. The objective of this study was to determine the effect of oat (Avena sativa L.), rye (Secale cereale L.), ...

http://bmj.com/cgi/content/full/323/7322/1177 Updated information and services can be found at: These include: Data supplement http://bmj.com/cgi/content/full/323/7322/1177/DC1 "Additional references" References http://bmj.com/cgi/content/full/323/7322/1177#otherarticles 10 online articles that cite this article can be accessed at: http://bmj.com/cgi/content/full/323/7322/1177#BIBL This article...

http://bmj.com/cgi/content/full/329/7475/1177 Updated information and services can be found at: These include: Data supplement http://bmj.com/cgi/content/full/329/7475/1177/DC1 "Further examples and references" References http://bmj.com/cgi/content/full/329/7475/1177#otherarticles 3 online articles that cite this article can be accessed at: http://bmj.com/cgi/content/full/329/7475/1177#BIBL Thi...

Animal models play a key role in the development of novel treatments for human disease. This is particularly true for rare diseases – defined as disorders that affect less than 1 in 2000 people in the human population – for which, very often, there are no effective methods of treatment. Pharmaceutical companies are increasingly focussing on the development of therapies for the more than 7000 ra...

BACKGROUND The authors describe the preclinical pharmacological properties of GAL-021, a novel peripheral chemoreceptor modulator. METHODS The ventilatory effects of GAL-021 were characterized using tracheal pneumotachometry (n = 4 to 6), plethysmography (n = 5 to 6), arterial blood gas analyses (n = 6 to 11), and nasal capnography (n = 3 to 4) in naive animals and those subjected to morphine...

In endothelial cells, two ways of endothelial nitric oxide (NO) synthase (eNOS) activation are known: 1) translocation and 2) Akt-dependent phosphorylation of the enzyme at Ser(1177) (Ser(1177) eNOS). We have recently shown that agonist-induced Ser(1177) eNOS phosphorylation also occurs in human myocardium (10). In this study, we investigated the Ca(2+) dependency of these two mechanisms in hum...

Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser-1177. In previous studies, we have demonstrated that stimulation of eNOS phosphorylation at Ser-1177 may be required, yet is not sufficient for insulin-stimulated NO synthesis. We therefore investigated the role of phosphoryla...

Jillian M. Lang, Department of Bioagricultural Sciences and Pest Management, Colorado State University, Fort Collins 80523-1177; David H. Gent, U.S. Department of Agriculture-Agricultural Research Service, National Forage Seed Production Research Center, Department of Botany and Plant Pathology, Oregon State University, Corvallis 97331-8539; and Howard F. Schwartz, Department of Bioagricultural...

GAL-021 and GAL-160 are alkylamino triazine analogues, which stimulate ventilation in rodents, non-human primates and (for GAL-021) in humans. To probe the site and mechanism of action of GAL-021 and GAL-160 we utilized spirometry in urethane anesthetized rats subjected to acute bilateral carotid sinus nerve transection (CSNTX) or sham surgery. In addition, using patch clamp electrophysiology w...