حي ت يو جذومنلأا ىلع يطخلا ريغ أ ،ءاملا ةمدص رث جاوملأاو يلاقتنلاا ه ، ةفاضإ ىلإ ضيف ءا ملا . مب ا نمق ه تءافآو ما ظنلا ة ناتم ة ساردلو أ ة شقان تاز يمملاو تابارط ضلاا ر ث (Parameters) ملا ر يغت ة بُ لطتيو ، مُيم صت ةَ فرعم ما ظنلا اذ ه ي ف ر يغتلا ىد م هذ ه مي ق تازيمملا . ةُقيرط تمدخُتسا دقو H ∞ يف دودحلا ةد يدع ميمصتلا . تا نارتقلاا را بتخا م ت ا مآ لا ة يكيمانيدلا ة ننقملا مكحت لل ة بولطملا ...

Counting the different subpopulations of cells in a fingerprick of human blood is important for a number of clinical point-of-care (PoC) applications. It is a challenge to demonstrate the integration of sample preparation and detection techniques in a single platform. In this paper we demonstrate a generic microfluidic platform that combines sample processing and characterisation and enumeratio...

Substitution therapies for orphan genetic diseases, including enzyme replacement methods, are frequently hampered by the limited availability of the required therapeutic substance. We describe the isolation of a pterin intermediate from bacteria that was successfully used for the therapy of a hitherto incurable and lethal disease. Molybdenum cofactor (Moco) deficiency is a pleiotropic genetic d...

Deconvoluting the molecular target signals behind observed drug response phenotypes is an important part of phenotype-based drug discovery and repurposing efforts. We demonstrate here how our network-based deconvolution approach, named target addiction score (TAS), provides insights into the functional importance of druggable protein targets in cell-based drug sensitivity testing experiments. U...

Large data sets on human genetic variation have been collected recently, but their usefulness for learning about history and natural selection has been limited by biases in the ways polymorphisms were chosen. We report large subsets of SNPs from the International HapMap Project1,2 that allow us to overcome these biases and to provide accurate measurement of a quantity of crucial importance for ...

-Adrenergic Pathway β the Norepinephrine Stimulates Apoptosis in Adult Rat Ventricular Myocytes by Activation of Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 1998 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.98.13.1329 1998;98:1329-1334 Circulation. http...