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The metabolism of delamanid (OPC-67683, Deltyba), a novel treatment of multidrug-resistant tuberculosis, was investigated in vitro using plasma and purified protein preparations from humans and animals. Delamanid was rapidly degraded by incubation in the plasma of all species tested at 37 C, with half-life values (hours) of 0.64 (human), 0.84 (dog), 0.87 (rabbit), 1.90 (mouse), and 3.54 (rat). ...

Previous studies have suggested a potential link between histamine H₃ receptors (H₃R) signaling and anxiolytic-like and antidepressant-like effects. The aim of this study was to investigate the acute effects of ST-1283, a novel H₃R antagonist, on anxiety-related and depression-related behaviors in comparison with those of diazepam and fluoxetine. The effects of ST-1283 were evaluated using the ...

BACKGROUND In our previous study, we found significant differences in the mRNA and microRNA (miRNA) levels among hypertensive patients with different degrees of vascular endothelial cells damage. These differences were closely associated with endoplasmic reticulum stress (ERS)-related proteins. Moreover, compared to the control group, the expression of transcription factor activating factor 4 (...

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published in: Lunar and Planetary Science XXXIV, CD-ROM, Lunar and Planetary Institute, Houston (2003). Lunar and Planetary Science XXXIV (2003) 1283.pdf

This paper presents results on a communications-intensive kernel, the three-dimensional fast Fourier transform (3D FFT), running on the 2,048-node Blue Genet/L (BG/L) prototype. Two implementations of the volumetric FFT algorithm were characterized, one built on the Message Passing Interface library and another built on an active packet Application Program Interface supported by the hardware br...