We report the long-term results of 51 pelvic osteotomies in 43 patients with a mean follow-up of 15 years (13 to 20). The mean age of the patients was 28 years (14 to 46). At review three patients were lost to follow-up, and six had received a total hip arthroplasty. Of 48 hips, 42 (88%) were preserved, with good to excellent clinical results in 27 (64%). Pre-operatively, 41 (80%) of the treate...

Matrix metalloproteinase (MMP)-1, MMP-8 and MMP-13 are interstitial collagenases that degrade type II collagen in cartilage; this is a committed step in the progression of rheumatoid arthritis and osteoarthritis. Of these enzymes, the expression of MMP-1 and MMP-13 is substantially increased in response to IL-1 and tumor necrosis factor-alpha, and elevated levels of these collagenases are obser...

objectives: knee osteoarthritis (oa) is a leading cause of disability in older adults. in current study, the effects of three types of orthoses on pain reduction were evaluated in oa patients in iran. methods & materials: in this prospective clinical trial, thirty six patients consisting of 11 men and 25 women with age (mean±sd) of 54.56±2.82 years and diagnosis of mild to moderate knee oa incl...

background: osteoarthritis is one of the most common diseases in synovial joints. dueto high loading forces during weight-bearing activities, the knee joint is prone to degenerative processes. this study aimed to compare the flexibility of muscles around the knee joint in patients with knee osteoarthritis with those of healthy individuals. methods: twenty-three women with bilateral knee osteoar...

background: osteoarthritis is a degenerative joint disorder of articular cartilage and is the most common type of arthritis in the elderly. there are only a few reports regarding the use of hydroxychloroquine in the treatment of osteoarthritis. methods: to investigate the effects of hydroxychloroquine on the symptoms of mild to moderate knee osteoarthritis (kellgren and lawrence grade ii and ii...

We report a patient who had bilateral stress fractures of proximal tibial shaft secondary to advanced osteoarthritis of knee with varus deformity. With treatment by simultaneous correction of deformity and internal fixation, the fractures healed uneventfully and the chronic knee pain was much alleviated. Due to progression of the symptom, right total knee replacement was finally performed 9 yea...

Objective and Background: Knee osteoarthritis is one of the most common musculoskeletal problems that is associated with impaired balance. The objective of this study was to investigate the effect of strengthening and balance on static stability indices in female with knee osteoarthritis. Materials and Methods:  In this randomized controlled single-blind clinical trial, 13 women with knee oste...

Background: microRNAs (miRNAs) are small non-coding RNAs that can ignite the degradation of mRNAs or inhibit protein translation and therefore essential for several physiological pathological functions. miRNAs regulate up to 60 % human mRNA, including genes related cartilage development, homeostasis, OA pathology. For example, miR-9 inhibits matrix metalloproteinase 13 miR-140 expression level ...

background: the present study aimed to translate and evaluate the reliability and validity of the persian version of the 11-item intermittent and constant osteoarthritis pain (icoap) measure in iranian subjects with knee osteoarthritis (koa). materials and methods: the icoap questionnaire was translated according to the manufacturers alliance for productivity and innovation (mapi) protocol. the...

Abstract Introduction: The present study aimed to review the condylar changes in the patients with osteoarthritis using cone beam computed tomography (CBCT) images. Methods: In this study, 80 CBCT images of the temporomandibular joint (TMJ) pertaining 20 patients with osteoarthritis and 20 healthy individuals were evaluated, as well as th...