Osteoarthritis is a chronic disease characterized by the destruction of cartilage in joints, causing stiffness, pain, and impaired movement. The condition most commonly affects joints knees, hands, feet, spine, often shoulders hips. Knee osteoarthritis major public health problem that causes pain reduces physical function quality life. This study determined relationship between degree level pat...

Osteoarthritis is a chronic joint disease that causes pain, disability, and loss of function. More than 80% cases osteoarthritis affect the knee joint. The exact cause still unknown, but it generally associated with aging obesity. This study aimed to determine relationship between age severity osteoarthritis. research used cross-sectional involving patients who suffered from Data on gender was ...

Osteoarthritis (OA) affects 250 million people worldwide. Currently, no targets for disease-modifying osteoarthritis drugs exist. Matrix metalloproteinase-13 (MMP-13) would make it an ideal target; however, its broad biological effects restrict its application as a target enzyme of inhibitory drugs in the treatment of OA. The expression and activation of discoidin domain receptor 2 (DDR2) is in...

BACKGROUND Anterior cruciate ligament (ACL) tear is considered a risk factor for osteoarthritis development. The purpose of our study was to investigate the expression levels of the apoptotic enzyme caspase 3, pro-inflammatory cytokines interleukin-1β (IL-1β) and interleukin-6 (IL-6) and degrading enzyme matrix metalloproteinase 13 (MMP-13), all indicative of cartilage degeneration and osteoart...

the association of obesity and other metabolic conditions with osteoarthritis is under debate; however, a strong link between metabolic disturbances is suggested to contribute to increased incidences and progression of osteoarthritis. we examined the association of metabolic syndrome and its components with the incidence of knee osteoarthritis in iranian population. a community-based study was ...

OBJECTIVES To investigate whether low-intensity pulsed ultrasound (US) has different protective effects on early and late rabbit osteoarthritis cartilage via the integrin/focal adhesion kinase (FAK)/mitogen-activated protein kinase (MAPK) signaling pathway. METHODS Thirty-six New Zealand White rabbits were divided into early control, early osteoarthritis, early treatment, late control, late o...

BACKGROUND Leg-length inequality is common in the general population and may accelerate development of knee osteoarthritis. OBJECTIVE To determine whether leg-length inequality is associated with prevalent, incident, and progressive knee osteoarthritis. DESIGN Prospective observational cohort study. SETTING Population samples from Birmingham, Alabama, and Iowa City, Iowa. PATIENTS 3026 ...