Objective(s): The aim of the present research is to investigate the efficacy of L-carnitine (LC) as a complementary therapy to diclofenac sodium (Dic) treatment in a mono-iodoacetate (MIA) induced knee osteoarthritis (OA) rat model, with respect to pain relief and the underlying pathology.Materials and Methods: Fifty adult male albino ra...

Abstract Transient receptor potential vanilloid 4 (TRPV4) plays an important role in chondrocytes via Ca 2+ signaling. However, its the progression of osteoarthritis is unclear. This study aimed to evaluate effects TRPV4 activation on articular cartilage and stimulated with interleukin (IL)-1?. Bovine human were various agents, including IL-1?, GSK1016790A (GSK101; a agonist), Compound C (an AM...

Osteoarthritis is a common chronic and progressively degenerative joint condition. The stem bark of Eucommia ulmoides Oliver (a member of the Eucommiaceae family), which is also known as Du-Zhong, is a traditional Chinese medicine commonly used for the treatment of rheumatoid arthritis. However, the mechanisms underlying the effects of Eucommia in the treatment of arthritis of the knee require ...

QUESTION Does behavioural graded activity result in better exercise adherence and more physical activity than usual care in people with osteoarthritis of the hip or knee? DESIGN Analysis of secondary outcomes of a cluster-randomised trial with concealed allocation, assessor blinding, and intention-to-treat analysis. PARTICIPANTS Two hundred patients with hip and/or knee osteoarthritis. IN...

OBJECTIVE This study aims to train students on public health survey; correlate risk factors of osteoarthritis and to identify modifiable risk factors. METHODS Osteoarthritis survey was carried out among 420 Bahraini women, above 40 years of age, diagnosed of osteoarthritis, attending ministry of health facilities. RESULTS Most cases in the study were from the age group of 50-59 years with a...

The metastasis-associated protein S100A4 promotes the progression of cancer by regulating the remodelling of the extracellular matrix. The expression of S100A4 in vivo is shown and the functional role of S100A4 in the pathogenesis of osteoarthritis and rheumatoid arthritisis is explored. The expression of S100A4 in rheumatoid arthritis, osteoarthritis and normal synovial tissues was determined ...