background: knee osteoarthritis is a common degenerative joint disorder and a major cause of pain and disability. recent studies have suggested that bisphosphonates such as alendronate may have a role in the treatment of osteoarthritis. the purpose of the present study was to investigate the potential effect of alendronate on the symptoms of knee osteoarthritis.  methods: thirty nine patients w...

OBJECTIVE To report on the results of the consensus process integrating evidence from preliminary studies to develop the first version of a Comprehensive ICF Core Set and a Brief ICF Core Set for osteoarthritis. METHODS A formal decision-making and consensus process integrating evidence gathered from preliminary studies was followed. Preliminary studies included a Delphi exercise, a systemati...

Osteoarthritis (OA) is the most common joint disorder and primarily affects older people. The ideal anti-OA drug should have a modest anti-inflammatory effect and only limited or no toxicity for long-term use. Because the antitussive medication dextromethorphan (DXM) is protective in atherosclerosis and neurological diseases, two common disorders in aged people, we examined whether DXM can be p...

Background and purpose - There is a lack of information on any associations between the functional outcome and age and diagnosis in patients who have undergone shoulder arthroplasty. We therefore evaluated the functional outcome in "young" and "old" patients treated with either hemiarthroplasty (HA) or total shoulder arthroplasty (TSA) with diverse diagnoses. Patients and methods - The function...

1 Felson DT, Naimark A, Anderson JJ, Kazis L, Castelli W, Meenan RF. The prevalence of knee osteoarthritis in the elderly: the Framingham osteoarthritis study. Arthritis Rheum 1987;30:914-8. 2 Badley EM, Tennant A. Disablement associated with rheumatic disorders in a British population: problems with activities of daily living and level of support. Br J Rheumatol 1993;32:601-8. 3 Fisher NM, Pre...

1. Australia Bureau of Statistics. National Health Survey, 1995. Canberra: ABS, 1995. 2. Segal L, Day S, Chapman A, et al. Priority setting in osteoarthritis — report to the Population Health Division, Department of Health and Ageing. Melbourne: Monash University Health Economics Unit, 2002. 3. Edelson R, Burks RT, Bloebaum RD. Short-term effects of knee washout for osteoarthritis. Am J Sports ...

The mechanism of endothelin-1 (ET-1)-induced nitric oxide (NO) production, MMP-1 production and MMP-13 production was investigated in human osteoarthritis chondrocytes. The cells were isolated from human articular cartilage obtained at surgery and were cultured in the absence or presence of ET-1 with or without inhibitors of protein kinase or LY83583 (an inhibitor of soluble guanylate cyclase a...

Scaphotrapeziotrapezoid (STT) joint osteoarthritis accounts for 13% of all wrist arthritis cases. The arthroscopic treatment combines radial midcarpal portal and STT portal called 1-2 midcarpal portal. We performed 13 isolated resections from the scaphoid distal pole. Patients were only women (average age, 58 years). Pain, mobility, and muscular strength improved significantly. At the same time...

BACKGROUND AND PURPOSE The long-term outcome of patellofemoral arthroplasty is related to progression of femorotibial osteoarthritis with need for conversion to total knee arthroplasty. We investigated whether prior patellofemoral arthroplasty compromises the results of total knee arthroplasty. METHODS 13 patients who had had 14 Richards type II patellofemoral arthroplasties converted to tota...