OBJECTIVES Some patients spend years with painful osteoarthritis without consulting for it, including times when they are experiencing persistent severe pain and disability. Beliefs about osteoarthritis and what primary care has to offer may influence the decision to consult but their relative importance has seldom been quantified. We sought to investigate the relative importance of perceived s...

diagnosis of knee osteoarthritis can be confirmed based on clinical and/or radiological features. the potential of a progressive disease can be prevented or decreased by earlier recognition and correction of associated factors. obesity and alignment especially varus malalignment are recognized factors of a progressive disease. both nonpharmalogical as well as pharmacological modalities of treat...

Although both the complement and contact system are thought to contribute to the inflammatory reaction in arthritic joints, only activation of complement has so far been well established, whereas contact activation and its contribution to arthritis has not been systematically explored. Complement and contact activation were assessed in 71 patients with inflammatory arthropathies and 11 with ost...

INTRODUCTION Collagen peptides have been reported to possess various biological activities for various cell types. The purposes of this study were, first, to examine the therapeutic effects of collagen tripeptide (Ctp) in rabbit osteoarthritis and, second, to explore a synergetic effect with hyaluronan (HA). METHODS Osteoarthritis was induced by anterior cruciate ligament transection of the r...

AIM To evaluate the therapeutic effects of domestic chicken collagen type II (CCII) on rat osteoarthritis (OA) and analyze concomitant changes in the level of Matrix metalloproteinase (MMP)-13, MMP-9, Cathepsin K and their mRNA as well as the tissue inhibitor of matrix metalloproteinase (TIMP)-1 mRNA in articular cartilage of osteoarthritic rats. METHODS Osteoarthritis models were surgically ...

A 10-year-old boy who sustained a fracture through a cyst in the ulna later developed a pseudarthrosis. During 13 years' follow-up the characteristic short bowed forearm developed but, instead of the more usual spontaneous dislocation of the head of the radius, the patient also developed the previously unreported complication of osteoarthritis of the elbow.

objective(s): osteoarthritis (oa), as a known degenerative joint disease, is the most common form of arthritis. in this study, we aimed to elucidate unclear pathogenesis of oa. materials and methods: rabbit models of oa were established by the transection of the anterior cruciate ligament. rabbits were randomly divided into three equal groups: the experimental group (oa modeling, treated with e...

conclusions in 88% of primary osteoarthritis cases we found fai morphology on the ap pelvic radiograph, similarly to those found in the bibliography, and we considered naming primary osteoarthritis, secondary osteoarthritis caused by fai. in the majority of cases, early diagnosis with simple, cheap and easily accessible ap pelvic radiograph with low dose of radiation may also be warranted backg...

background: osteoarthritis is a disabling musculoskeletal disease with no definite treatment. this study compared the effect of platelet-rich plasma (prp) and transcutaneous electrical nerve stimulation (tens) plus exercise in the treatment of patients with knee joint osteoarthritis.   methods : 54 eligible patients with knee osteoarthritis were randomly allocated into two groups. (irct20121106...

OBJECTIVES To compare the efficacy and safety of single versus combination non-prescription oral analgesics in community-derived people aged 40 years and older with chronic knee pain. METHODS A randomised, double-blind, four-arm, parallel-group, active controlled trial investigating short-term (day 10) and long-term (week 13) benefits and side-effects of four regimens, each taken three times ...