OBJECTIVES Recent studies have shown that systemic injection of rapamycin can prevent the development of osteoarthritis (OA)-like changes in human chondrocytes and reduce the severity of experimental OA. However, the systemic injection of rapamycin leads to many side effects. The purpose of this study was to determine the effects of intra-articular injection of Torin 1, which as a specific inhi...

INTRODUCTION The aims of this study were, first, to investigate the in vivo effects of treatment with avocado/soybean unsaponifiables on the development of osteoarthritic structural changes in the anterior cruciate ligament dog model and, second, to explore their mode of action. METHODS Osteoarthritis was induced by anterior cruciate ligament transection of the right knee in crossbred dogs. T...

.37. Boileau C, Martel-Pelletier J, Brunet J, et al. Oral treatment with PD-0200347, anα2δ ligand, reduces the development ofexperimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes. Arthritis Rheum. 2005 Feb;52(2):488-500.38. Pelletier JP, Lascau-Coman V, Jovanovic D, et al. Selectiv...

BACKGROUND The purpose of this study was to describe the effectiveness of a single one-hour consultation by a clinical nurse specialist in patients with hand osteoarthritis during daily rheumatology practice in secondary care. METHODS Consecutive patients diagnosed by rheumatologists to have primary hand osteoarthritis and referred to the clinical nurse specialist were eligible for entry into...

BACKGROUND Hand osteoarthritis (HOA) is typified by pain and reduced function. We hypothesised that people with HOA have enhanced sensitivity and activation of peripheral nociceptors in the hand, thereby potentiating chronic pain. In our study we aimed to assess if central sensitisation mediates pain perception in osteoarthritis of the hand. METHODS Participants with proximal and distal inter...

The aim of this study was to evaluate and compare the effectiveness three different intra-articular injective treatments: hyaluronic acid (HA), autologous conditioned serum (ACS) bone marrow aspirate concentrate (BMAC) for treatment knee osteoarthritis (OA). A Level III retrospective comparative clinical performed on 505 consecutive patients treated with HA (n = 171), ACS 222) or BMAC 112) OA. ...

OBJECTIVE Recommended outcome measures in osteoarthritis are standardised scales identical for each patient. As patient-specific scales are of increasing interest when considering patient priorities in outcome assessment, this study aims to validate individualised forms of the Western Ontario and McMaster Universities osteoarthritis index (WOMAC) function subscale. PATIENTS AND METHODS WOMAC ...