We have solved the structure of a chorismate mutase (chorismate pyruvatemutase, EC 5.4.99.5), the 1.9-A crystal structure of the monofunctional enzyme from Bacillus subtilis. The structure determination process was an unusual one, involving 12 monomers of the enzyme in the asymmetric unit. This structure was solved by the multiple isomorphous replacement method with partial structure phase comb...

Methods We randomly assigned patients admitted to the ICU after major abdominal oncology surgery to receive either GDT protocol or usual care. The GDT protocol involved hemodynamic optimization aimed at a target of a cardiac index >2.5 L/minute/m2 (by minimally invasive cardiac output monitoring) and a mean arterial pressure of 70 mmHg through a three-step approach: fluid therapy of 250 ml albu...

Botulism caused by neurotoxins of Clostridium (C.) botulinum is a rare, but serious life-threatening disease in humans and animals. Botulism in livestock is usually caused by the oral uptake of C. botulinum neurotoxins (BoNT) via contaminated feed and is characterized by flaccid paralysis. In the recent past a new syndrome caused by BoNT in dairy cattle was postulated. It was supposed that C. b...

CONCLUSION The papers collected in our study demonstrated that there were no significant differences in the effectiveness of sound transmission and stability of the prosthesis between the titanium and non-titanium group. However, further randomized controlled trials with large sample sizes are needed to improve the estimation. OBJECTIVE To compare the effectiveness of sound transmission and s...

Plastic waste has become a growing concern in terms of marine pollution, but little information is available on plastic debris and its possible risks chemical additives exposure the deep-sea. This study focused identification polymer type additive concentrations 21 collected from deep-sea Sagami Bay, Japan West Pacific Ocean under Kuroshio Extension recirculation gyre (KERG) zone (water depth: ...

İslam hukuku tarihine baktığımızda fıkıh usûlünün bir süreç içerisinde geliştiğini söylemek mümkündür. Bu içerisinde, mezhep imamları de-diğimiz müçtehitler başta olmak üzere birçok âlimin, usûlü ilminin yapısını oluşturan katkılarından bahsedilebilir. Örneğin İmam Ebû Hanîfe’nin (ö. 150/767) istihsana başvurması, Mâlik’in 179/795) amel-i ehli Medine ile amel etmesi ve Şafiî’nin 204/820) hem Eh...

Objectives: Gender has been reported to be an independent predictor of stent thrombosis (ST), however, very limited data are available regarding gender disparities in the incidence ST after primary percutaneous coronary intervention (PCI). Therefore, objective this study was compare among males and females PCI. Methodology: In study, we included consecutive patients diagnosed with ST-elevation ...

Objectives: (i) Describe the prevalence and type of advance care directives (ACDs) other planning (ACP) documentation completed by persons with dementia, healthcare providers others on behalf a person dementia; (ii) identify personal ACP programme characteristics associated having in health record; (iii) self-completed ACD. Methods: A multicentre audit was undertaken Australian hospitals, ge...