OBJECTIVE The University of California at Los Angeles (UCLA) Scleroderma Clinical Trial Consortium GI Tract Instrument (UCLA SCTC GITI) was recently developed to measure gastrointestinal tract disease in systemic sclerosis (SSc). Our study assesses the internal consistency and validity of the instrument in a different population than was used in the original study. METHODS A sample of 113 con...

Giti Shams, Elham Foroughi, Melanie W. Moretz, Bunmi O. Olatunji Roozbeh Hospital, Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran Department of Psychology, School of Behavioral Science, The University of Melbourne, Melbourne, Australia Ferkauf Graduate School of Psychology, Yeshiva University, New York, USA Department of Psychology, Vanderbilt University, Nashvill...

PURPOSE The pipecolinate derivative VX-710 (biricodar; Incel) is a clinically applicable modulator of P-glycoprotein (Pgp) and multidrug resistance protein (MRP-1); we studied its activity against the third multidrug resistance (MDR)-associated drug efflux protein, breast cancer resistance protein (BCRP). EXPERIMENTAL DESIGN VX-710 modulation of uptake, retention, and cytotoxicity of mitoxant...

The envelope removal method has the advantage of suppressing background spectrum and expanding weak absorption characteristic information. However, for second-class water bodies with a relatively complex quality, there are few studies on inversion chlorophyll (Chl-a) concentration in that consider spectral characteristics. In addition, current research Chl-a was carried out under condition samp...

PURPOSE Incel (biricodar, VX-710) restores drug sensitivity to P-glycoprotein and multidrug resistance-associated protein-1-expressing cells. This Phase I/II study evaluated the safety/tolerability, pharmacokinetics, and efficacy of VX-710 plus doxorubicin in patients with inoperable, locally advanced or metastatic, anthracycline-resistant/refractory, soft tissue sarcoma. EXPERIMENTAL DESIGN ...

Purpose: To evaluate wide-diameter (ie, 5.5-mm-wide) Frialit-2 implants used for several forms of prosthetic rehabilitation. Materials and Methods: In this retrospective study, 121 wide implants (74 maxillary, 47 mandibular) were placed in 114 patients (61 female, 53 male, mean age 37.2 ± 14.9 years). Thirty-six single-tooth restorations, 63 fixed partial dentures (68 implants), 6 removable ove...