Many of the specific functions of intrinsically disordered protein segments are mediated by Short Linear Motifs (SLiMs) interacting with other proteins. Well known examples include SLiMs that interact with 14-3-3, PDZ, SH2, SH3, and WW domains but the true extent and diversity of SLiM-mediated interactions is largely unknown. Here, we attempt to expand our knowledge of human SLiMs by applying i...

Tricyclic ring systems, possessing the dibenzo structure joined to the central seven membered heterocyclic ring with a basic side chain, have been a rich source of biologically active molecular entities and frequently show effects on the central nervous system [10]. The precise mechanism of action of these compounds is not known [2]. Therefore to further elucidate the mechanism of action and to...

A rapid and sensitive silver ion high-performance liquid chromatographic (Ag[I]-HPLC) method is developed for the simultaneous determination of the biologically active diterpenoids andrographolide, 14-deoxy-11,12-didehydroandrographolide, 14-deoxyandrographolide, and neoandrographolide in Andrographis paniculata Nees. HPLC is carried out for determining andrographolide and its derivatives with ...