Fatty acid amide hydrolase (FAAH) inactivates the endogenous cannabinoid (endocannabinoid) anandamide and related lipid transmitters in vivo. A single nucleotide polymorphism (SNP) in the human FAAH gene (385C to A) has recently been described that, in homozygous form, is over-represented in subjects with problem drug use. This SNP, which converts a conserved proline residue in FAAH to threonin...

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The application of modeling and simulation techniques is increasingly common in the preclinical stages of the drug development process. GDC-0917 [(S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(2-(oxazol-2-yl)-4-phenylthiazol-5-yl)pyrrolidine-2-carboxamide] is a potent second-generation antagonist of inhibitor of apoptosis (IAP) proteins that is being developed for the trea...

Advances in Agronomy, Volume 90 Copyright 2006, Elsevier Inc. All rights reserved. 0065-2113/06 $35.00 DOI: 10.1016/S0065-2113(06)90005-4 II. M echanistic Studies of Cell Wall Adsorption A . P artitioning Relationships Versus Surface Complexation Modeling B . C onstraints on Bacterial Cell Wall‐Protonation Reactions C . C onstraints on Mechanisms of Metal Adsorption onto Bacteria I II. C hallen...

[This retracts the article on p. 2113 in vol. 8.].

Byproducts from the winery industry contain many bioactive compounds that are considered high-value-added compounds. White grape pomace (GP) is rich in carbohydrates; consequently, it can be used as a raw material for subsequent bioprocesses. In present study, low-temperature hydrothermal treatments were carried out using different operational conditions regarding temperature (65–95 °C), time (...

Using photoelectron spectroscopy in combination with synchrotron radiation, we have observed previously inaccessible vibrational excitation of HI+ X 2113,z, X 2111,2 final ionic states. The vibrational enhancement is shown to be caused by strongly predissociating autoionization resonances converging to HI+ A ?Z+. Molecular vibrational constants are extracted from the photoelectron spectra obtai...

Organic agriculture (OA) is practiced on 1% of the global agricultural land area and its importance continues to grow. Specifically, OA is perceived by many as having less Advances inAgronomy, ISSN 0065-2113 © 2016 Elsevier Inc. http://dx.doi.org/10.1016/bs.agron.2016.05.003 All rights reserved. 1 ARTICLE IN PRESS