The developing central nervous system may be particularly sensitive to bisphenol A (BPA)-induced alterations. Here, pregnant Sprague Dawley rats (n = 11-12/group) were gavaged daily with vehicle, 2.5 or 25.0 μg/kg BPA, or 5.0 or 10.0 μg/kg ethinyl estradiol (EE2) on gestational days 6-21. The BPA doses were selected to be below the no-observed-adverse-effect level (NOAEL) of 5 mg/kg/day. On pos...

It is well known that estrogenic compounds affect development of fertilized eggs of many species of birds, fish and amphibians through disrupted activity of carbonic anhydrase (CA). The most potent activity comes from the most commonly occurring synthetic sterol, 17α-Ethynylestradiol (EE2). Less is known about the responses of aquatic phytoplankton to these compounds. Here we show for the first...

Abstract The increasing occurrence of steroidal hormone micropollutant in the aquatic environment and their associated consequences have caused serious environmental concerns globally. Adsorptive removal hormonal pollutants using polymeric membranes has been suggested but information on performance various conditions is lacking. In this study, we examined effect salinity polyethersulfone (PES) ...

This work aimed at the degradation of synthetic estrogen 17α-ethinyl estradiol (EE2) via a combined photoelectrocatalysis (PEC) and peroxymonosulfate (PMS) process. Pristine TiO2/WO3 photoanodes were fabricated used in this work. The removal 1 mg L−1 EE2 increased from 47.9 % to 88.8 60 min by adding 10 PMS an external bias V. was degraded presence 0.05 M sodium sulfate as electrolyte. rate con...

After once-daily oral dosing in ovariectomized rats, raloxifene (LY139481) hydrochloride produced dose- and time-dependent reductions in serum cholesterol and high-density lipoprotein-cholesterol. Paired-feeding studies demonstrated that effects of raloxifene on serum lipids were not secondary to effects on food consumption. Maximal reductions in serum cholesterol occurred within 4 days of ralo...

Proses induk lele (Clarias gariepinus Burchell) betina menjadi matang gonad secara alami memakan waktu hingga 2-3 bulan, dengan tingginya permintaan benih diperlukan percepatan proses pematangan agar dapat terpenuhi, salah satunya melalui pemberian hormon ethinylestradiol. Kandungan optimum ethinylestradiol pada tubuh akan mempercepat vitellogenesis sehingga memacu pertumbuhan oosit dan kematan...

BACKGROUND Ethinylestradiol was used as palliative treatment for patients with advanced prostate cancer (PCa). However, its use has declined after the development of combined androgen blockade. In the present study, we analyzed the effects of ethinylestradiol on pretreated castration-resistant PCa patients. PATIENTS AND METHODS Twenty-four Japanese patients were orally administered ethinylest...