نتایج جستجو برای: 17 β estradiol e2
تعداد نتایج: 488447 فیلتر نتایج به سال:
17 -hydroxysteroid dehydrogenase type 1 (17 -HSD1) was chosen as a key steroidogenic target enzyme to reduce the formation of estradiol (E2), which is the most potent estrogen. This article completes a previous study by synthesizing and testing 16 -methylene derivatives (Br, Cl and OH) of E2 in order to generate new structure-activity relationships. This study also investigates a series of 2-me...
The working hypotheses in this experiment were: that ovarian estradiol would inhibit luteinizing hormone (LH) secretion in heifers that were anestrus as a result of restricted dietary energy intake and the responsiveness of LH secretion to estradiol negative feedback would decrease during the period when restoration of estrous cycles occurred following feeding of diets adequate in energy. Fifte...
this study was conducted to evaluate the effect of soy milk on serum 17- β estradiol level and number of neurons in cerebral cortex and hippocampus as well as determination of the ratio of neurons in cortical and hippocampal regions in neonatal ovariectomized rats. thirty female rats (one day old) were divided into six groups of five. at day 7, ovariectomy surgery was performed in four groups a...
The aim of this study was to examine the changes in serum cytokine levels (Il-1α, Il-6, TNF-α) in ovariectomized rats with and without replacement estrogen therapy. Female Wistar rats were used. Rats were qualified for the following groups: Cl control, SH sham-operated, OV after ovariectomy, OVH after ovariectomy receiving 17 β-estradiol in three different doses (1.25, 12.5, 125 μg) during seve...
Koshman YE, Piano MR, Russell B, Schwertz DW. Signaling responses after exposure to 5 -dihydrotestosterone or 17 -estradiol in norepinephrine-induced hypertrophy of neonatal rat ventricular myocytes. J Appl Physiol 108: 686–696, 2010. First published December 31, 2009; doi:10.1152/japplphysiol.00994.2009.—Androgens appear to enhance, whereas estrogens mitigate, cardiac hypertrophy. However, sig...
BACKGROUND Female fecundity is regulated by nutritional status. Although widely cited, this hypothesis is not strongly supported by empirical data from non-obese, healthy women of reproductive age. METHODS Healthy, reproductive aged women (n = 141) from Southern Poland collected daily morning saliva samples for one complete menstrual cycle. Levels of 17-beta-estradiol were analyzed by radioim...
INTRODUCTION The purpose of the study is to compare the effects of genistein, estradiol, estradiol/progesterone combination on the bone mineral density and biomechanical properties of ovariectomized rats' bone. METHODS 50 female adult Sprague-Dawley rats were divided into five groups. Bilaterally ovaeriectomy were performed in all groups except the sham-operated group. Groups were a sham-oper...
These experiments were undertaken to determine the potential for estradiol-17 beta (E2), 2-hydroxyestradiol-17 beta (2-OH-E2) and 4-hydroxyestradiol-17 beta (4-OH-E2) to regulate prostaglandin (PG) E and F2 alpha synthesis by pig endometrium. Endometrium was collected from pigs on d 10 of pregnancy and incubated (15 to 20 mg/well) for three 2-h periods in 2 ml of medium in 24-well culture plate...
Excess 17beta-estradiol (E2), the most potent of human estrogens, is known to act as a stimulus for the growth of breast tumors. Human estrogenic 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1), which catalyzes the reduction of inactive estrone (E1) to the active 17beta-estradiol in breast tissues, is a key enzyme responsible for elevated levels of E2 in breast tumor tissues. We presen...
The data presented here are related to the research article entitled "Estradiol-independent modulation of breast cancer transcript profile by 17beta-hydroxysteroid dehydrogenase type 1" (J.A. Aka, E.L. Calvo, S.X. Lin, 2016) [1]. We evaluated the effect of the steroidal enzyme 17β-HSD1 and its product, the estrogenic hormone 17-beta-estradiol (E2), on gene transcription profile of breast cancer...
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