Positron Emission Tomography (PET) with 2-deoxy-2-(18F)fluoro-D-glucose ([18F]FDG) is an integral part of the diagnostic workup in patients with suspected or confirmed cancer. The ability of the (18F)FDG-PET study to characterize and detect malignancies can be increased by dual-phase acquisition; this is due to the different kinetics of the radiotracer in the tumor tissue and in the background....

A 65-year-old male patient with a one year history of liver transplantation was referred for an 18F-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) to rule out post transplant lymphoproliferative disease. Multiple foci of intense abnormal 18F-FDG uptake were seen in the transplanted liver which were concerning for malignancy. Explantation of the live...

PURPOSE To determine the value of diffusion-weighted MRI (DWI-MRI) for pretherapeutic imaging of fluorodeoxyglucose (FDG)-avid lymphoma and lymphoma with variable FDG avidity. EXPERIMENTAL DESIGN Treatment-naïve patients with lymphoma who were referred for whole-body staging were included in this prospective study. Group A included patients with FDG-avid lymphoma (e.g., Hodgkin, diffuse large...

Background Brain age (BA) provides a proxy of general brain health through the prediction chronological (CA) from neuroimaging data healthy individuals. During aging, adult undergoes changes both on morphological and metabolic level. Here, we compare link between BA predicted morphology (structural MRI) or metabolism (18F-FDG-PET) cognitive function, as well pathophysiological measures Alzheime...

The study is based upon 80 patients, suspected of having recurrent laryngeal cancer, who underwent an 18F-FDG PET study on a coincidence camera and a laryngoscopic biopsy under general anaesthesia. The potential value of 18F-FDG PET in the detection of local relapses of laryngeal cancer after radiotherapy by use of a coincidence camera was prospectively assessed, and a cost-effectiveness analys...

The purpose of our study was to determine the value of different hybrid imaging combinations for the detection of focal and diffuse bone marrow infiltration in lymphoma. Patients with histologically proven lymphoma, who underwent both [18F]-FDG-PET/CT and whole-body MRI (including T1- and diffusion-weighted [DWI] sequences) within seven days, and a subsequent bone marrow biopsy, were retrospect...

PURPOSE Besides its application in oncology, 18F-FDG PET-CT imaging is also useful in the diagnosis of certain lung infections, inflammatory diseases, and atherosclerotic plaques. Myocardial uptake of 18F-FDG may hamper visualization of the lesions caused by these diseases. Two approaches have been proposed for reducing myocardial uptake in preclinical studies, namely, calcium channel blockers ...

18F-FDG is formed through radiochemical synthesis from cyclotron-produced 18F (K. Breslow, written communication, June 2000). Production of 18F is through proton bombardment of enriched 18O-water. 18F-fluoride is bound to 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-Dmannopyranose (mannose triflate) under conditions of a stereospecific second-order nucleophilic substitution reaction, whi...

For 18F-FDG PET to be widely used to monitor atherosclerosis progression and therapeutic response, it is crucial to better understand how macrophage glucose metabolism is influenced by the atherosclerotic microenvironment and to elucidate the molecular mechanisms of this response. Oxidized low-density lipoprotein (oxLDL) is a key player in atherosclerotic inflammation that promotes macrophage r...

BACKGROUND Increasing plasma glucose levels and insulin resistance can alter the distribution pattern of fluorine-18-labeled fluorodeoxyglucose (18F-FDG) in the brain and relatively reduce 18F-FDG uptake in Alzheimer's disease (AD)-related hypometabolic regions, leading to the appearance of an AD-like pattern. However, its relationship with plasma insulin levels is unclear. We aimed to compare ...