INTRODUCTION....................................................................................1078 I. WHAT ARE DESIGNER DRUGS AND WHERE DID THEY COME FROM?...............................................................1081 A. The Federal Analog Act: History of Designer Drugs ..............1081 B. The Source of Designer Drugs: A Close Relationship Between the Pharmaceutical Industry and Clande...

Recent studies have demonstrated that orally administered thiazolidinedione ligands of the peroxisome proliferator-activated receptor-gamma can ameliorate clinical features of psoriasis in humans. Thiazolidinediones also inhibit the proliferation of psoriatic keratinocytes in monolayer and organ culture, and at least one of these agents (troglitazone) inhibits epidermal hyperplasia of human pso...

I Hartzman, R. J., Segall, M., Bach, M. L., and Bach, F. H., Transplantation, 1971, 11, 268. 2 Bernard, A., Thesis, Paris, 1973. 3 Dupont, B., Andersen, V., Sonderstrup Hansen, G., Transplantation. In press. 4 Meuwissen, H. J., Bach, F. H., Hong, R., and Good, R. A., 7ournal of Pediatrics, 1968, 72, 177. 5 Golley, D. G., Shih Wu, A. Y., and Wakssman, B. H., Yournal of Experimental Medicine, 197...

MicroRNAs (miRNAs) regulate gene expression post-transcriptionally by binding the 3¢ untranslated regions of target mRNAs. We examined the subcellular distribution of three miRNAs in exponentially growing HeLa cells and found that the vast majority are associated with mRNAs in polysomes. Several lines of evidence indicate that most of these mRNAs, including a known miRNA-regulated target (KRAS ...

A total of 288 broiler chickens (1 d old) were used in a 42-d growth trial to study the effects of chicory (Cichorium intybus) and nettle (Urtica dioica) with or without multi-enzyme on growth performance, carcass traits, and biochemical parameters. The corn-soybean based control diet and 8 experimental diets were fed to each of 3 pens of chickens (12 chickens/pen). Treatments were as follows: ...

U d o E n g e l h a r d t * u n d T h o m a s B ü n g e r Institut für Anorganische Chemie der Freien Universität Berlin, Fabeckstraße 34-36, D-1000 Berlin 33 Z. Naturforsch. 84b , 1107-1111 (1979); eingegangen a m 30. März /18 . Mai 1979 Tetraalkyl-dichloro-disiloxanes, N M R , I R , R a m a n Phenoxy-thiophosphoryl -d ihydrazide C 6 H 5 O P ( S ) ( N H N H 2 ) 2 ( la) and phenoxy-phos phoryl-...

a total of 288 broiler chickens (1 d old) were used in a 42-d growth trial to study the effects of chicory (cichorium intybus) and nettle (urtica dioica) with or without multi-enzyme on growth performance, carcass traits, and biochemical parameters. the corn-soybean based control diet and 8 experimental diets were fed to each of 3 pens of chickens (12 chickens/pen). treatments were as follows: ...

Stem cell persistence into adulthood requires self-renewal from early developmental stages. In the developing mouse brain, only apical progenitors located at the ventricle are self-renewing, whereas basal progenitors gradually deplete. However, nothing is known about the mechanisms regulating the fundamental difference between these progenitors. Here we show that the conditional deletion of the...

The protoberberine alkaloid berberine carries methylenedioxy moiety and exerts a variety of pharmacological effects, such as antiinflammation and lipid-lowering effects. Berberine causes potent CYP1B1 inhibition, whereas CYP1A2 shows resistance to the inhibition. To reveal the influence of oxidative metabolism on CYP1 inhibition by berberine, berberine oxidation and the metabolitemediated inhib...

Schizophrenia is a chronic, complex and heterogeneous mental disorder, with pathological features of disrupted neuronal excitability and plasticity within limbic structures of the brain. These pathological features manifest behaviorally as positive symptoms (including hallucinations, delusions and thought disorder), negative symptoms (such as social withdrawal, apathy and emotional blunting) an...