We herein describe the rapid synthesis of a diverse set of dihydroquinazolin-4-ones and quinazolin-4-ones, their biological evaluation as thyroid stimulating hormone receptor (TSHR) agonists, and SAR analysis. Among the compounds screened, 8b was 60-fold more potent than the hit compound 1a, which was identified from a high throughput screen of over 73,000 compounds.

a simple and efficient procedure has been developed for the synthesis of 2,3-dihydroquinazolin-4(1h)-ones derivatives under solvent-free conditions. this method uses the condensation of isatoic anhydride, aldehydes, and amines in the presence of a catalytic amount sulfonated porous carbon (spc). one of the important advantages of the new method is that the spc could be recycled and reused.

A novel and cost-effective catalyst for synthesis of 2,3'-dihydroquinazolin-4-(1H)-ones was developed utilizing a combined nanocomposite obtained from bonding TiCl3 to hydroxyl groups of nanofibrillated cellulose as a green and inexpensive support.The structure of the catalyst was investigated using the Fourier transform infrared spectroscopy (FT-IR), field emission scanning...

Synthesis of 2,3-dihydroquinazolin-4(1H)-ones using H3BO3/montmorillonite K10 (H3BO3/mont K10) catalyst has been reported. H3BO3/mont K10 and H3BO3/mont K30 have been prepared and used as catalysts in the reaction between anthranilamide and benzaldehyde to prepare 2-phenyl...