Dataflow graphs that are strongly consistent and have finite complete cycles can always be scheduled statically and executed in bounded memory. Some strongly consistent graphs without finite complete cycles can also be executed in bounded memory. We have described a clustering technique that can identify such graphs and construct their schedules. However, some perfectly correct graphs may not f...

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IL-22 plays an important role in mucosal epithelial cell homeostasis. Using a dextran sodium sulfate-induced mouse model of acute colitis, we observed an IL-23-dependent up-regulation of IL-22 in the middle and distal colon at the onset of epithelial cell damage. This heightened IL-22 correlated with an influx of innate immune cells, suggesting an important role in colonic epithelial protection...

This vignette provides an introduction to the analysis of ChIP-seq data with ‘mosaics’ package. R package mosaics implements MOSAiCS, a statistical framework for the analysis of ChIP-seq data, proposed in [1]. MOSAiCS stands for“MOdel-based one and two Sample Analysis and Inference for ChIP-Seq Data”. Based on careful investigation of biases in ChIP-seq data such as mappability and GC content, ...

A child with many symptoms of trisomy 22 syndrome is described. The child showed a 46,XY/47,XY,+22 chromosome constitution. This is the first reported case of a trisome 22 phenotype with such a mosaic karyotype.

Four randomised controlled trials (RCTs) and one RCT metaanalysis are featured in the Journal this month. The latter is a review of trials of newer-generation antidepressants and cognitive–behavioural therapy (CBT) for adolescent depression (Dubicka et al, pp. 433–440). In an area of clinical practice plagued by controversy, the authors of this review were able to contribute the finding that ad...