This research, involved synthesis of a series of new compound containing different derivatives. The synthesis involved treatment of 6methyl 2-thiouracil with chloroacetyl chloride to give 1chloroacetyl 6methyl 2-thiouracil (1) .The product was treat with hydrazine hydrate to give 2( aceto hydrazide ) thiouracil (2), and with phenyl hydrazine to give phenyl hydrazide thiouracil (13). The new der...

This research includes synthesis of new heterocyclic containing (1,3-oxazepine) derivatives 6- methyl 2-thiouracil. The preparation process started by the reaction 2-thiouracil with ethyl chloroacete to give 2-((4-hydroxy-6-methylpyrimidin-2-yl) thio) acetate (1). Compound (1) reacted hydrazine hydrate 2-((4-hydroxy-6-methylpyrimidin-2-yl)thio) aceto hydrazide (2). That various substituted benz...

The electrochemical oxidation of methyl catechol in the presence of 2-thiouracil (as a nucleophile) has beenperformed in aqueous solutions using cyclic voltammetry and controlled-potential coulometric techniques.The electrochemical behavior of methyl catechol in the presence of 2-thiouracil was investigated. Theelectrochemical synthesis of this compound has been successfully performed in an und...

In recent years, questions have been raised on the possible semi-endogenous status of the alleged xenobiotic thyreostatic drug thiouracil; thiouracil has been detected in the urine of various animals (livestock and domesticated) at concentrations between 1 and 10 μg L(-1) and also in human urine. Although several studies suggest Brassicaceae-derived feed as potential origin, no traces of thiour...

Bielschowsky (2) reported the occurrence of carcinoma in the rat's thyroid gland made hyperplastic by administration of allyl thiourea when the carcinogen, 2-acetaminofluorene (AAF) was administered simultaneously. Applying a similar principle, we investigated the effects of administration of this carcinogen to rats in which hyperplasia of target organs was produced by injection of male and fem...

the electrochemical oxidation of methyl catechol in the presence of 2-thiouracil (as a nucleophile) has beenperformed in aqueous solutions using cyclic voltammetry and controlled-potential coulometric techniques.the electrochemical behavior of methyl catechol in the presence of 2-thiouracil was investigated. theelectrochemical synthesis of this compound has been successfully performed in an und...

Transfer RNAs isolated from Escherichia coli B grown in the presence of 2-thiouracil are deficient in pseudouridine. Much of this deficiency is from the T psi C region, which has only about 50% of its normal pseudouridine content. The other modified nucleoside from this region, ribothymidine, is reduced by only about 10%. Studies showed that 2-thiouracil is incoproated into the RNA of E. coli d...

In a survey of various substrates for pyrimidine nucleoside synthesis, it was noted that inorganic orthophosphate was released when 2-thiouracil and desoxyribose-l-phosphate were incubated together with thymidine phosphorylase (1). This finding, taken as a fairly certain indication of nucleoside synthesis, has now been fully substantiated by isolation and characterization of crystalline thioura...