The molecular complex lumiflavin-2-aminobenzoic acid monohydrate (C13H12N4O2.C7H7NO2.H2O) crystallizes from from aqueous solution as red triclinic prisms. The space group is P1 with cell dimensions a = 9.660 A, b = 14.866 A, c = 7.045 A, alpha = 95.44 degrees , beta = 95.86 degrees, and gamma = 105.66 degrees . The crystal structure was solved by direct methods and refined by block-diagonal lea...

It has been known for many years that p-aminobenzoic acid at high concentration is inhibitory to a variety of organisms, including rickettsiae (I), bacteria (2, 3), fungi (4), protozoa (5), and plants (6). The site of inhibition by p-aminobenzoic acid in most of these organisms has not been established. However, Davis (3) has shown that the bacteriostatic activity of p-aminobenzoic acid toward ...

pteroic acid and dihydrofolic acid from p-aminobenzoic acid and p-aminobenzoylglutamic acid, respectively, in the presence of pyrophosphorylmethyldihydropteridine. In the enzymatic reaction, p-aminobenzoic acid was more active as substrate than p-amino benzoylglutamic acid. When p-aminobenzoic acid and L-glutamic acid were used in place of p-aminobenzoic acid in the enzyme system, dihydropteroi...

The discovery by Woods (1940) that small amounts of p-aminobenzoic acid could block the antibacterial effects of the sulfonamides served to stimulate a number of investigations on sulfonamide p-aminobenzoic acid relationships. Woods's initial finding soon led to the observations that many derivatives of p-aminobenzoic acid also exhibited antisulfonamide activity. Keltch et al. (1941) demonstrat...

Using the substrate N-acetyl-L-tyrosyl-p-aminobenzoic acid, we determined chymotrypsin activity in the small intestine of calf, pig, and poultry. Orally administered N-acetyl-L-tyrosyl-p-aminobenzoic acid is enzymatically cleaved in vivo, and the released p-aminobenzoic acid is determined by HPLC. We found that the p-aminobenzoic acid concentration in plasma and urine was significantly influenc...

Para-Aminobenzoic acid is supported on silica gel via reaction of activated silica gel and p-aminobenzoic acid which is then converted to its manganese and cobalt salts. A mixture of the manganese and cobalt salts of the acid is used to catalyze allylic and benzylic alcohols to their corresponding carbonyl compounds in reasonable yields using oxygen or air. Reactions are clean and the catal...

1. Strains of staphylococci produce diazotizable materials which can be converted to a dye, and the intensity of the color reaction can be quantitated in the same manner as p-aminobenzoic acid. The sulfonamide-resistant strains which we have studied produce more diazotizable substance than non-resistant strains. 2. The development of a color by the diazotizable substance can be inhibited by exp...