BACKGROUND The polycomb complex protein BMI-1 (BMI-1) is a putative oncogene reported to be overexpressed in multiple myeloma (MM). Silencing of BMI-1 was shown to impair the growth and survival of MM cells. However, therapeutic agents specifically targeting BMI-1 were not available so far. Here, we investigated PTC-209, a novel small molecule inhibitor of BMI-1, for its activity in MM. METHO...

Multiple myeloma (MM) is a tumor of plasmablasts/plasma cells (PCs) characterized by the expansion of malignant PCs with complex genetic aberrations in the bone marrow (BM). Recent reports, by us and others, have highlighted the polycomb group (PcG) proteins as potential targets for therapy in MM. The PcG protein BMI-1 of the polycomb repressive complex 1 (PRC1) has been reported to be overexpr...

Alzrigat, M. 2017. Targeted Inhibition of Polycomb Repressive Complexes in Multiple Myeloma. Implications for Biology and Therapy. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1296. 53 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9805-4. Multiple myeloma (MM) is a hematological malignancy of antibody producing plasmablasts/ plasma cells. ...

This paper reports the applicability of low-pressure gas chromatography-mass spectrometry operated in electron-capture negative ionization mode (LP-GC-ECNI-MS) for the analysis of decabrominated diphenyl ether (BDE-209). Particular attention was paid to find optimal injector and oven conditions for minimal thermal degradation of BDE-209. The analytical characteristics were compared for LP-GC co...

The study concerns 170 cases of hypertension in women where the systolic blood pressure was estimated at 200 mm. Hg. or more, the average systolic being 209 mm. and the average diastolic 117 mm. The cases have been observed over a period of from one to eight years. Patients with valvular or renal lesions have been excluded. The majority of the women have attended the Out-Patient Clinic of the H...

The study concerns 170 cases of hypertension in women where the systolic blood pressure was estimated at 200 mm. Hg. or more, the average systolic being 209 mm. and the average diastolic 117 mm. The cases have been observed over a period of from one to eight years. Patients with valvular or renal lesions have been excluded. The majority of the women have attended the Out-Patient Clinic of the H...

A new drug delivery system for H2 receptor antagonist Ranitidine hydrochloride, was developed utilizing both the concepts of adhesiveness and of flotation, in order to obtain a unique drug delivery system which could remain in the stomach for a much longer period of tim Floating-Mucoadesive tablets of Ranitidine hydrochloride were developed to prolong its release and improve bioavailability. Ra...

The effects of ketotifen, meloxicam, phenyramidol-HCl and gadopentetic acid on the enzyme activity of GR were studied using human erythrocyte glutathione reductase (GR) enzymes in vitro. The enzyme was purified 209-fold from human erythrocytes in a yield of 19% with 0.31 U/mg. The purification procedure involved the preparation of haemolysate, ammonium sulphate precipitation, 2'',5'-ADP Sepharo...

Building on gene–environment interaction (G E) research, this study examines how the dopamine D4 receptor (DRD4) gene interacts with a situational prime of religion to influence prosocial behavior. Some DRD4 variants tend to be more susceptible to environmental influences, whereas other variants are less susceptible. Thus, certain life environments may be associated with acts of prosociality fo...