Here we report the synthesis, pharmacological and pharmacokinetic evaluation of a pilot set of compounds structurally related to the potent and selective 5-HT7 ligand LP-211. Among the studied compounds, N-pyridin-3-ylmethyl-3-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]ethoxy]propanamide (4b) showed high affinity for 5-HT7 receptors (K(i)=23.8 nM), selectivity over 5-HT1A receptors (>50-fold)...

Background. Few studies have measured, using validated scales, the psychosocial handicap of epilepsy in a general practice setting. Aim. To assess the prevalence of psychosocial problems associated with epilepsy. Method. A survey was undertaken of 309 subjects, with one or more non-febrile epileptic seizures, drawn from two general practices in the United Kingdom (UK). The outcome measures were...

The Pacific Decadal Oscillation (PDO) and North Pacific Gyre Oscillation (NPGO) are the two dominant lowfrequency modes in the North Pacific. This study focused on the simulation capability of the two leading lowfrequency modes in current-coupled models, based on 24 coupled model outputs from the Coupled Model Intercomparison Project Phase 5 (CMIP5). Results showed that most of these models cap...

with a range of problem outcomes during childhood, adolescence and adulthood. Adults who were victims of child sexual abuse often fear sex, distrust their sex partners, have decreased sexual drive and have multiple superficial sexual relationships.1 Some children who were sexually abused have been found to engage in sexualized behavior (e.g., atypical sexual play with dolls and playmates, or ex...

Our previous study has suggested that downregulated microRNA (miR)-29a in denatured dermis might be involved in burn wound healing. However, the exact role of miR-29a in healing of burn injury still remains unclear. Here, we found that expression of miR-29a was notably upregulated in denatured dermis tissues and skin fibroblast cells after thermal injury, and thereafter gradually downregulated ...