نتایج جستجو برای: 22-dehydrocholesterol
تعداد نتایج: 212275 فیلتر نتایج به سال:
Using a sterol auxotroph of the LM cell mouse fibroblast, we demonstrate that relatively few cholesterol analogues can substitute for cholesterol as a growth factor. The auxotroph grows normally on desmosterol and trans-22-dehydrocholesterol and at reduced rates on dihydrocholesterol, campesterol, and 22,23-dihydrobrassicasterol. It does not grow with beta-sitosterol, stigmasterol, ergosterol, ...
The Smith-Lemli-Opitz syndrome (SLOS) is a common birth defect-mental retardation syndrome caused by a defect in the enzyme that reduces 7-dehydrocholesterol to cholesterol. Because of this block, patients' plasma cholesterol levels are generally low while 7-dehydrocholesterol concentrations are markedly elevated. In addition, plasma total sterols are abnormally low and correlate negatively wit...
Panagrellus redivivus produced 24-methyl-23-dehydrocholesterol as 4.0% of the 4-desmethylsterols when propagated in a medium containing campesterol as the dietary sterol. The re-examination of previous data revealed that Caenorhabditis elegans produced 1.8% 24-methyl-23-dehydrocholesterol when propagated in medium containing campesterol. 24-Methyl-23-dehydrocholesterol was not detected when the...
Cultures of Tetrahymena pyriformis were incubated with a series of sterols which differed from one another in the steric character of their side chains. (E)-1X20)-Dehydrocholesterol in which C-22 is fixed to the right (bans with respect to C-13, “right-handed”) in the usual view of the molecule was converted to its A5,7,17(2”’ and A5v7,17(20)22 derivatives; however, the organism did not signifi...
The protozoan Tetrahymena pyriformis was incubated in a growth medium containing added unlabeled cholesterol or 26-14C-cholesterol with the following consequences: (a) the biosynthesis of tetrahymanol, a pentacyclic triterpenoid alcohol produced in the organism by squalene cyclization, was inhibited, and (b) the cholesterol was accumulated by the cells and converted metabolically to a mixture o...
Until now it had been assumed that mammalian skin contains only one provitamin D, 7-dehydrocholesterol, that is eventually converted to vitamin D3 after the skin is exposed to sunlight. Examination by reverse phase high performance liquid chromatography of lipid extracts from young rat skin, however, led to the observation that 7-dehydrocholesterol is not the only provitamin D in rat skin. Anot...
Smith-Lemli-Opitz syndrome (SLOS) is a severe autosomal recessive disorder resulting from defects in the cholesterol synthesising enzyme 7-dehydrocholesterol reductase (Δ7-sterol reductase, DHCR7, EC 1.3.1.21) leading to a build-up of the cholesterol precursor 7-dehydrocholesterol (7-DHC) in tissues and blood plasma. Although the underling enzyme deficiency associated with SLOS is clear there a...
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