Among the indolocarbazole alkaloids of antitumor antibiotics, K-252a represents a structurally unique indolocarbazole glycoside and exhibits potent neuroprotective and broad anticancer activities. K-252a consists of K-252c and the unusual dihydrostreptose moiety, linked together with oxidative and glycosidic C-N bonds. Herein, we reported a complete sequence of an approximately 45 kb genomic fr...

A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) via a sequential C–H functionalisation strategy is reported. The route exploits direct functionalisation reactions around a simple arene core and comprises of two highly-selective copper-catalysed C–H arylations, a coppercatalysed C–H amination and a palladium-catalysed C–H carbonylation, which build up the structura...

GIBSON, N" 1988 (31 :x): A description of the Huon pine (Lagarostrobos franklinii (Hook. f.) C,J. Quinn) forests of the Prince of Wales and King Billy Ranges. Pap. Proc. R. Soc. Tasm. 122(2); 127--133, ISSN 0080-4703. Department of Geography and Environmental Studies, University of Tasmania, G.P.O. Box 252C, Hobart, Tasmania, Australia 700 I; formerly National Parks and Wildlife Service, Tasmania.

GILFEDDER, L. & KIRKPATRICK, J.B., 1996 The distribution, ecology and conservation needs of Colobanthus curtisiae West. Pap. Proc. R. Soc. Tasm. 130(1): 25-30. ISSN 0080-4703. Department of Geography & Environmental Studies, University of Tasmania, GPO Box 252C, Hobart, Australia 7001 QBK and formerly LG), LG now Parks and Wildlife Division, DELM, GPO Box 44A, Hobart, Tasmania, Australia 7001 (...

A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) via a sequential C-H functionalisation strategy is reported. The route exploits direct functionalisation reactions around a simple arene core and comprises of two highly-selective copper-catalysed C-H arylations, a copper-catalysed C-H amination and a palladium-catalysed C-H carbonylation, which build up the structur...

As the usage of handheld digital camcorders increase amongst the general population, the problem of undesired motions being introduced into captured video sequences will become ever more prevalent. Even the slightest movements on the part of the user will introduce these undesired motions, and unfortunately users will find it difficult to remain absolutely stable for any amount of time. These u...

The indolocarbazole family of natural products has attracted great attention because of their unique structural features and potential therapeutic applications. Structurally distinct in the family, K-252a is characterized by an unusual dihydrostreptose moiety cross-bridged to K-252c aglycone with two C-N linkages. K-252a has served as a valuable lead for treatments of various cancers and neurod...

Kinase inhibitors are widely employed as biological reagents and as leads for drug design. Their use is often complicated by their lack of specificity. Although binding conserved ATP sites accounts for some of their nonspecificity, some compounds inhibit proteins not known to bind ATP. It has been found that promiscuous hits from high-throughput screening may act as aggregates. To explore wheth...

ORCHARD, A.E. & DAVIES, J.B., 1985 (3I:vii): Oreoporanthera, a New Zealand "endemic" plant genus discovered in Tasmania. Pap. Proc. R.Soc. Tasm. 119:61-63. ISSN 0080-4703. Tasmanian Herbarium, GPO Box 252C, Hobart, Tasmania, and Department of Agriculture, Marine Board Building, Hobart, Tasmania. Recent collections near Mt Anne in southwestern Tasmania have extended the known range of the previo...

Lobeline attenuates the behavioral effects of methamphetamine via inhibition of the vesicular monoamine transporter (VMAT2). To increase selectivity for VMAT2, chemically defunctionalized lobeline analogs, including lobelane, were designed to eliminate nicotinic acetylcholine receptor affinity. The current study evaluated the ability of lobelane analogs to inhibit [³H]dihydrotetrabenazine (DTBZ...