The SCL gene encodes a basic helix-loop-helix transcription factor which is expressed in early haematopoietic progenitors throughout ontogeny and is essential for the normal development of blood and blood vessels. Transgenic studies have characterised spatially distinct 5' enhancers which direct lacZ expression to subdomains of the normal SCL expression pattern, but the same elements failed to ...

In Caenorhabditis elegans, an insulin-like signaling pathway, which includes the daf-2 and age-1 genes, controls longevity and stress resistance. Downregulation of this pathway activates the forkhead transcription factor DAF-16, whose transcriptional targets are suggested to play an essential role in controlling the phenotypes governed by this pathway. We have surveyed the genes that have the D...

This study describes and presents the analysis for the Source-Coupled Logic (SCL) inverter as will as the effect of submicron layout parasitics. The SCL inverter circuit model and its operation is defined. The analysis for the SCL is carried from the point of view of input/output voltage characteristics and the effect of noise margin. The inverter gate delay model is described and the effect of...

The stem cell leukemia gene SCL, also known as TAL-1, encodes a basic helix-loop-helix transcription factor expressed in erythroid, myeloid, megakaryocytic, and hematopoietic stem cells. To be able to make use of the unique tissue-restricted and spatio-temporal expression pattern of the SCL gene, we have generated a knock-in mouse line containing the tTA-2S tetracycline transactivator under the...

The product of the SCL gene is a basic helix-loop-helix (bHLH) transcription factor that is essential for the development of hematopoietic stem cells in both the embryo and the adult. However, once the stem cell compartment is established, the function of SCL in subsequent differentiation and commitment events within normal hematopoietic cells remains undefined. The aim of the current study was...

Purpose This paper aims to provide a comprehensive understanding of the supply chain learning (SCL)–performance relationship based on existing empirical evidence. Design/methodology/approach We sampled 54 studies SCL–performance relationship. proposed conceptual research framework and adopted meta-analytical approach analyse Findings The results meta-analysis confirm positive effects SCL perfor...

The Symptom Checklist 90 Revised (SCL-90-R) is a widely used assessment of mental health pathology. Its factor structure has been called into question by numerous studies. This study assessed a community mental health outpatient sample (n = 336) with the SCL-90-R and analyzed the factor structure. The results indicated that the SCL-90-R measures one large factor, but the test items held togethe...

The T cell leukemia oncoprotein SCL/tal-1, a basic-helix-loop-helix transcription factor, is required for production of embryonic red blood cells in the mouse yolk sac. To define roles in other lineages, we studied the hematopoietic potential of homozygous mutant SCL/tal-1 -/- embryonic stem cells upon in vitro differentiation and in vivo in chimeric mice. Here we show that in the absence of SC...

Multiple excitatory and inhibitory interneurons form the motor circuit with motor neurons in the ventral spinal cord. Notch signaling initiates the diversification of immature V2-interneurons into excitatory V2a-interneurons and inhibitory V2b-interneurons. Here, we provide a transcriptional regulatory mechanism underlying their balanced production. LIM-only protein LMO4 controls this binary ce...