The main role of fatty acids is focused on serving as major substrates for energy production; however, fatty acids are also involved in the formation of cellular structures as well as in the transmission of cellular signals. Among the multiple functions attributed to fatty acids are their anti-inflammatory properties. This important characteristic has been applied in the prevention, attenuation...

There are now several examples of plant species engineered to synthesize and accumulate nutritionally important polyunsaturated fatty acids in their seed triacylglycerols (TAG). The utilization of TAG in germinating seeds of such transgenic plants was unknown. In this study, we examined the TAG utilization efficiency during seed germination in transgenic Arabidopsis seeds containing several exa...

Age-related macular degeneration (AMD) is a leading cause of vision loss and blindness among older people. It is important to identify modifiable risk factors which could prevent or slow the progression of this chronic disease. Dietary fatty acid intakes have been investigated in epidemiological studies as it is plausible that individual lipids have properties which modulate cellular damage in ...

Th17 response following in vitro exposure to mercury with and without n-3 long chain polyunsaturated fatty acids peripheral blood mononuclear cells from systemic lupus erythematosus patients compared healthy controls - Volume 82 Issue OCE4

OBJECTIVE To examine the associations between reported intakes of dietary fat and incident type 2 diabetes. RESEARCH DESIGN AND METHODS We studied the relation between dietary fatty acids and diabetes in a prospective cohort study of 35,988 older women who initially did not have diabetes. Diet was assessed with a food frequency questionnaire at baseline, and 1,890 incident cases of diabetes o...

Subcutaneous or oral administration of the polyunsaturated fatty acid linoleic acid prolongs survival of skin allografts in mice. Mice fed on a diet deficient in polyunsaturated fatty acids show a relative immunopotentiation, as indicated by accelerated skin allograft rejection and decreased incidence and rate of development of methylcholanthrene-induced tumors. These observations support the h...

Isoelectric solubilization /precipitation (ISP) process was used to isolate protein from muscles of Prussian carp, Carassius gibelio (Bloch, 1782). Fish protein and lipid were recovered from whole gutted Prussian carp using acidic and basic isoelectric solubilization/precipitation followed by assaying amino acid and fatty acid profile. Essential amino acids content in acidic and basic pH treatm...

TLRs provide critical signals to induce innate immune responses in APCs such as dendritic cells (DCs) that in turn link to adaptive immune responses. Results from our previous studies demonstrated that saturated fatty acids activate TLRs, whereas n-3 polyunsaturated fatty acids inhibit agonist-induced TLR activation. These results raise a significant question as to whether fatty acids different...