OBJECTIVE To evaluate the efficacy and safety of BHT-3009 in relapsing-remitting multiple sclerosis (MS) and to confirm that BHT-3009 causes immune tolerance. METHODS BHT-3009 is a tolerizing DNA vaccine for MS, encoding full-length human myelin basic protein. Relapsing-remitting MS patients were randomized 1:1:1 into three groups: placebo, 0.5 mg BHT-3009, or 1.5 mg BHT-3009, given intramusc...

OBJECTIVE To assess safety and immune modulation by BHT-3009, a tolerizing DNA vaccine encoding full-length human myelin basic protein, in patients with multiple sclerosis (MS). DESIGN The study was a randomized, double-blind, placebo-controlled trial. Subjects receiving placebo were crossed over into an active arm after treatment unblinding. SETTING The trial was conducted at 4 academic in...

2.1. Kinetic Resolution of Alcohols and Amines 2987 2.2. Ketene Acylation 2995 2.3. Cycloadditions 2996 2.3.1. â-Lactone Formation 2996 2.3.2. â-Lactam Formation 2997 2.3.3. Ketene Dimerization 2999 2.4. Halogenation 3000 2.5. Baylis−Hillman Reactions 3000 2.6. Desymmetrization of Cyclic Anhydrides 3002 2.7. C-Acylation 3004 2.8. Cyanation 3004 3. Solid Phase Chemistry 3007 3.1. Solution Cataly...

Context. Reports on a transient source about 1.25 • south of the Galactic Centre motivated these follow-up observations with the WSRT and the reinvestigation of archival VLA data. The source GCRT J1745-3009 was detected during a 2002 Galactic Centre monitoring programme with the VLA at 92 cm by five powerful 10-min bursts with a 77-min recurrence while apparently lacking any interburst emission...

GCRT J1745-3009 is a peculiar transient radio-source in the direction of the Galactic Center. It was observed to emit a series of ∼ 1 Jy bursts at 0.33 GHz, with typical duration ∼ 10 min and at apparently regular intervals of ∼ 77 min. If the source is indeed at the distance of the Galactic Center as it seems likely, we show that its observational properties are compatible with those expected ...

A bursting radio source, GCRT J1745-3009, had been discovered by Hyman et al. (2005) near the direction of the Galaxy center. It bursts with a period of ∼ 77 min and a duration of ∼ 10 min. The source is very luminous during its burst state, which implies that it is not an incoherent emitter. It is still open to explain this phenomenon although a couple of scenarios had been proposed by Hyman e...

A unique transient bursting radio source, GCRT J1745-3009, has been discovered (Hyman et al. 2005a) near the direction of the Galactic center. It is still an open question to explain this phenomenon, although some efforts to understand its nature have been made. This paper shows that most of the observed features can be reproduced by our proposed precessing pulsar model. It is found that the pr...