(51) Int. Cl. GOIS 7102 (2006.01) GOIS13166 (2006.01) GOI S 13100 (2006.01) (52) U.S. Cl . ................ 342/60; 342/73; 342/74; 342/75; 342/81; 342/89; 342/175; 342/195; 342/368 (58) Field of Classification Search .................... 342/52, 342/58, 60, 73-81, 104-116, 159-164, 175, 342/192-197, 368-384, 89; 244/3.1-3.3; 343/753-755, 757-766, 772, 781 R, 782, 343/781 P, 781 CA, 832-840, 84...

An update to the American Cancer Society (ACS) guideline regarding screening for the early detection of cervical neoplasia and cancer, based on recommendations from a formal review and recent workshop, is presented. The new screening recommendations address when to begin screening, when screening may be discontinued, whether to screen women who have had a hysterectomy, appropriate screening int...

Most postprandial studies have investigated the response of a single meal, yet the ingestion of sequential meals is more typical in a Western society. The aim of this review is to explain how natural and stable isotope tracers of fatty acids have been used to investigate the metabolism of dietary fat after single and multiple meals, with a focus on in vivo measurements of adipose tissue metabol...

Almost half of prescription medications are metabolized by cytochrome P450 3A4 and 3A5. CYP3A4 and 3A5 have significant substrate overlap, and there is currently no way to selectively monitor the activity of these two enzymes, which has led to the erroneous habit of attributing the cumulative activity to CYP3A4. While CYP3A4 expression is ubiquitous, CYP3A5 expression is polymorphic, with large...

In vertebrates, the digestive tract develops from a uniform structure where reciprocal epithelial-mesenchymal interactions pattern this complex organ into regions with specific morphologies and functions. Concomitant with these early patterning events, the primitive GI tract is colonized by the vagal enteric neural crest cells (vENCCs), a population of cells that will give rise to the enteric n...

OBJECTIVE The involvement of microRNAs in cancer and their potential as biomarkers of prognosis are becoming increasingly appreciated. The aim of this study was to evaluate the clinical importance and prognostic value of miR-342-3p in hepatocellular carcinoma (HCC). PATIENTS AND METHODS RT-PCR was used to detect the expression of miR-342-3p. The association with clinicopathologic features was...

Julen Hernandez Lallement, Katarina Kuss, Peter Trautner, Bernd Weber, Armin Falk, and Klaus Fliessbach Center for Economics and Neuroscience, University of Bonn, Nachtigallenweg, 53113 Bonn, Germany, Department of Comparative Psychology, Institute of Experimental Psychology, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany, Department of Epileptology, University Hospital Bonn, S...

Pregnancy-induced changes in drug pharmacokinetics can be explained by changes in expression of drug-metabolizing enzymes and transporters and/or normal physiology. In this study, we determined gestational age-dependent expression profiles for all metabolic enzyme and transporter genes in the maternal liver, kidney, small intestine, and placenta of pregnant mice by microarray analysis. We speci...

342 NATURE | VOL 399 | 27 MAY 1999 | www.nature.com A micro-Raman spectrometer was used for the further characterization of the deposited diamond. A laser beam of 1-mm spot size was focused onto the crystallites. Figure 3 shows the resulting Raman spectrum: it exhibits a first-order diamond peak centred at 1,332.8 cm. The high intensity of the diamond peak, its small full-width at half-maximum ...