Herba Epimdii is a traditional Chinese medicine used to treat osteoporosis. Its main pharmacological ingredients are flavonoids. In previous studies conducted in healthy animals, we showed that epimedium flavonoids could be hydrolyzed into secondary glycosides or aglycon by intestinal flora or enzymes, thereby enhancing their absorption and antiosteoporosis activity. To study the medicine in th...

Centre for Health Economics and Medicines Evaluation, Bangor University, Bangor; South East Wales Trials Unit, Cardiff University, Cardiff; School of Healthcare Sciences, Cardiff University, Cardiff, UK; Department of Biobehavioral Sciences, Columbia University, New York, NY, USA; Oxford Institute of Nursing and Allied Health Research, Oxford Brookes University, Oxford; and Cardiff Brain Repair...

study medicine in 1536 and supported himself by lecturing on mathematics, geography and astronomy. In Paris, his teachers included Sylvius and Andermach, who hailed him with Andrea Vesalius as his most able assistant in dissections There he stepped over the line that Christian doctrine had drown between acceptable areas of astrology, and forbidden zone of judicial astrology (left for God-essent...

BACKGROUND Treatment of metastatic colorectal cancer (CRC) with raltitrexed results in an objective response rate (OR) and overall survival (OS) comparable to bolus 5-fluorouracil (5-FU). A phase III trial found raltitrexed to be inferior to continuous infusion of 5-FU (ci5-FU). PATIENTS AND METHODS This phase II trial studied the activity and toxicity of methotrexate-modulated ci5-FU (ci5-FU...

4 Department of Biomedical Sciences, University of Bradford, Bradford, UK 8 9 Corresponding Author: Professor Silley 10 Telephone: +44 1590 678700 11 Fax: +44 1590 678751 12 Email: [email protected] 13 14 Running Title: Activity of pradofloxacin against agents of periodontal disease 15 16

4 Department of Biomedical Sciences, University of Bradford, Bradford, UK 8 9 Corresponding Author: Professor Silley 10 Telephone: +44 1590 678700 11 Fax: +44 1590 678751 12 Email: [email protected] 13 14 Running Title: Activity of pradofloxacin against agents of periodontal disease 15 16

AIM Supplementary functional information can contribute to assess response in targeted therapies. The aim of this study was to evaluate semi-automatic RECIST plus iodine uptake (IU) determination in melanoma metastases under BRAF inhibitor (vemurafenib) therapy using dual-energy computed tomography (DECT). METHODS Nine patients with stage IV melanoma treated with a BRAF inhibitor were include...

Objective(s): 5-FU, an anticarcinogenic agent, is reported to have side-effects that include hepatotoxicity and nephrotoxicity. The study objective was to investigate the protective effects of naringin on 5-FU-induced hepatotoxicity and nephrotoxicity.Materials and Methods: Thirty rodents were assigned to three groups. The control group received 1 ml of intragastric distilled water for 14 days....

Osmanlı toplumu bir içecek olarak kahveyle 16. yy. başlarında tanışmış, yüzyılın ortalarında başkentinde kahvehanelerin açılması ile kahve kültürü yayılmıştır. Kahveye rağbetin artmasının sonucu olarak, çiğ kahvenin kavrulup çekilmesi için ihdas edilmiş olan tahmishane ortaya çıkmıştır. İstanbul’da ilk tahmishane, Tahtakale’de, bugün de Tahmis Sokağı adlandırılan bölgede, 1590’lı yıllarda kurul...

OBJECTIVE To filtrate breast cancer resistance protein (BCRP)-mediated resistant agents and to investigate clinical relationship between BCRP expression and drug resistance. METHODS MTT assay was performed to filtrate BCRP-mediated resistant agents with BCRP expression cell model and to detect chemosensitivity of breast cancer tissue specimens to these agents. A high performance liquid chroma...