نتایج جستجو برای: 4 aminosalicylic acid

تعداد نتایج: 1924350  

Journal: :The Journal of biological chemistry 1948
A VENKATARAMAN P R VENKATARAMAN H B LEWIS

The importance of p-aminosalicylic acid in the treatment of tuberculosis has been demonstrated both clinically and experimentally (l-6). The close structural relationships between benzoic, salicylic, p-aminobenzoic (PABA), and p-aminosalicylic (PASA) acid warrant a comparative study of the metabolism of these substances in the animal body.* Recent workers, interested in the behavior of PABA in ...

Journal: :Gut 1999
P Deltenre A Berson P Marcellin C Degott M Biour D Pessayre

BACKGROUND Treatment of ulcerative colitis or Crohn's disease with sulphasalazine causes several adverse effects, including hepatitis. Sulphasalazine is cleaved by colonic bacteria into 5-aminosalicylic acid and sulphapyridine. Received wisdom was that 5-aminosalicylic acid was topically active, whereas sulphapyridine was absorbed and caused immunoallergic side effects. Mesalazine, a slow relea...

Journal: :Journal of bacteriology 2001
C Deloménie S Fouix S Longuemaux N Brahimi C Bizet B Picard E Denamur J M Dupret

Arylamine N-acetyltransferase activity has been described in various bacterial species. Bacterial N-acetyltransferases, including those from bacteria of the gut flora, may be involved in the metabolism of xenobiotics, thereby exerting physiopathological effects. We characterized these enzymes further by steady-state kinetics, time-dependent inhibition, and DNA hybridization in 40 species, mostl...

Journal: :Postgraduate medical journal 1982
N Nagaratnam N Bhuvanendran A J Jiffry V Ramachandra

This report describes a patient who developed a Hodgkin's disease-like picture both clinically and pathologically, following the administration of para-aminosalicylic acid, with complete regression on cessation of therapy.

Journal: :British medical journal 1972
I C Calder C C Funder C R Green K N Ham J D Tange

5-Aminosalicylic acid given to rats as a single intravenous injection led to necrosis of the proximal convoluted tubules and of the renal papilla. These two lesions developed at the same time and the cortical lesions did not appear to be a consequence of the renal papillary necrosis. Since the compound possesses the molecular structure both of a phenacetin derivative and of a salicylate these o...

Journal: :Gut 1994
S Schreiber S Howaldt A Raedler

4-Aminosalicylic acid (4-ASA) has been suggested as an effective treatment for both active and quiescent ulcerative colitis. 5-Aminosalicylic acid (5-ASA) is well accepted for the maintenance treatment of inactive ulcerative colitis. Moreover, recent studies suggest that 5-ASA may also be effective in maintaining remission in Crohn's colitis. As treatment with 4-ASA may result in less side effe...

Objective(s): This study is aimed to design and synthesize a prodrug of 5-aminosalicylic acid and evaluate its ameliorative effect on experimental ulcerative colitis (UC).Materials and Methods: 5-Aminosalicylic acid-alanine (5-ASA-ALA) was synthesized and characterized. Its stability study was conducted in rat plasma and in the gastroint...

Journal: :Angewandte Chemie 2021

Amine-tagged defective Ni-MOF-74 was prepared by solvothermal synthesis using aminosalicylic acid as a functionalized fragmented ligand, described Seung Bin Baek, Myoung Soo Lah et al. in their Communication on page 9296. The covalent post-synthetic modification and subsequent metalation with palladium(II) ions affords palladium(II)-incorporated catalyst, which exhibits highly efficient, size-s...

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