Pyrazolo[1,5-a]pyridines and 6-iodopyrazolo[1,5-a]pyridines were synthesized by gold-catalyzed and iodine-mediated cyclization of enynylpyrazoles in good to excellent yields, respectively. The iodinated adducts were further converted to 6-arylpyrazolo[1,5-a]pyridines via Suzuki-Miyaura coupling reaction and 6-cyanopyrazolo[1,5-a]pyridine by Ullmann condensation reaction. One of the cyclization ...

An important direction of modern pharmaceutical science is the creation promising biologically active compounds, which in hands scientists can be transformed into effective medicinal products. Heterocyclic compounds are undisputed leader solving this problem. A well-known fact and a well-founded approach to achieving desired pharmacological effect combination different heterocyclic fragments st...