Megazol is a highly active compound against Trypanosoma cruzi, and has become a core structure for the design of new trypanocidal agent. Recently, a new potent trypanocide agent Brazilizone A (a derivatives of megazol), was identified which presents an IC50 two fold more potent than the prototype megazol. This result has encouraged us to perform QSAR study on structurally-related 1,3,4-thiadiaz...

Reactions of the salicylaldehyde 4-phenylthiosemicarbazone (H(2)L) with selected vanadium(iv) and vanadium(v) precursors ([VO(acac)(2)], [VO(OAc)(2)], VOSO(4), [V(2)O(4)(acac)(2)]) were investigated under aerobic conditions in different alcohols (methanol, ethanol, propanol). In all examined cases mononuclear alkoxo vanadium(v) complexes [VOL(OR)] (1) (OR = OMe, OEt, OPr) were isolated as major...

Co-assembled structures possessing tunable light emission from 510-690 nm have been prepared using various compositions of two different 4,7-substituted benzothiadiazole molecules, 1 and 2. The preferential incorporation and co-localization of 1 and 2 to produce co-assemblies are possible because of structural similarities and allow for tuning of morphology and light emission.

Novel A-D-A type oligothiophenes incorporating benzothiadiazole (BTDA) and thiadiazolopyridine (TDAPy) as terminal acceptor groups have been developed for small molecule organic solar cells (SMSC). In vacuum-processed planar heterojunction solar cells the TDAPy-based oligomer showed a power conversion efficiency of 3.15% and a high fill factor of 0.67.

Metal complexes of the title ligand (L) containing Co(II), Ni(II) and Cu(II) were prepared and characterized by elemental analysis, IR, electronic spectroscopy and conductimetry. The new derivatives, possessing the following formulae, CuL(2)(OH)(2), NiL(2)Cl(2), and [Co(2)LCl(4)](n) showed in vitro antifungal activity against Aspergillus and Candida spp.

A low band-gap alternating copolymer of indolocarbazole and benzothiadiazole-cored oligothiophene demonstrated balanced crystallinity and solubility; a solar cell combining this polymer with PC(61)BM in a preliminary test demonstrated power conversion efficiencies of 3.6%.

Thiadiazoles are an important class of heterocyclic compounds that exhibit diverse applications in organic synthesis, pharmaceutical and biological applications. They also known to useful as oxidation inhibitors, cyanine dyes, metal chelating agents, anti-corrosion agents. Attracted by their broad spectrum of applications; researchers across the globe are working on this moiety and consequently...

1,3,4-Thiadiazole skeleton forms an integral part of various medicinal agents and depicts a vast array of biological activities such as antimicrobial, anti-inflammatory, analgesic, antileishmanial, antitumor, anti-tuberculosis, antileptic, antiviral and other activities. 1,3,4-Thiadiazole moiety has many desirable features which makes them pharmaceutically suitable as it can act as “hydrogen bi...

A new series of 6-(aryl/heteryl)-3-(5-methyl-1-phenyl-1H-4-pyrazolyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (7a-j) has been synthesized by the reaction of 4-amino-5-(5-methyl-1-phenyl-1H-4-pyrazolyl)-4H-1,2,4-triazol-3-yl-hydrosulfide (6) with POCl(3) and the corresponding aryl/heteryl carboxylic acid, in ethanol at reflux temperature for 12 h. All the synthesized compounds were tested for i...