A series of novel bis 1,2,3-triazole derivatives 2-Hydroxyquinoline-4-carboxylate, exhibiting diverse molecular structures were synthesized through a click reaction, incorporating combination moieties and quinoline nucleus. In vitro biological studies conducted to evaluate their antitubercular, antibacterial antifungal activities. To explore the behavioural selective properties molecules, exper...

Tuberculosis (TB) ranks second, next to AIDS making it most formidable disease if the present age. One of the crucial enzymes involved in cell wall synthesis of Mycobacterium tuberculosis, InhA (enoyl acyl carrier protein reductase) has been authenticated as an effective target for anti-mycobacterial drug development. In the current work, we have developed novel derivatives of 1,2,4-triazole-5-...

1,2,4-Triazole and its derivatives are a promising class of organic compounds. For long time, they remain in the spotlight due to number unique properties: high ability chemical transformations, presence various types biological activity and, course, low toxicity. Also, 1,2,4-triazole currently well studied implemented spheres human life as effective drugs, plant protection products (growth sti...

The synthesis of a series of 1,2,3-triazoles using glycerol as starting material is described. The key step in the preparation of these triazolic derivatives is the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), also known as click reaction, between 4-(azidomethyl)-2,2-dimethyl-1,3-dioxolane (3) and different terminal alkynes. The eight prepared derivatives were evaluated with regard t...

A new synthetic route leading to functionalized 1H-1,2,3-triazole-4-carbonitriles has been developed. set of 1-aryl-5-methyl-1H-1,2,3-triazole-4-carbonitriles was obtained in high yields from readily available starting 1H-1,2,3-triazole-4-carboxylic acids via several protocols. Synthesized were examined as promising precursors the simple and efficient method for preparation 2-triazol-4-yl-thien...

The synthesis of saccharin (1,2-benzisothiazol-3-one-1,1-dioxide) derivatives substituted on the benzene ring has seen limited development despite the longevity of this compound's use as an artificial sweetener. This type of saccharin derivative would however present attractive properties for the development of new bioactive, drug-like small molecule compounds. Here we report the derivatisation...