Treatment of 3-acetonyl-5-cyano-1,2,4-thiadiazole (1) with 4-methyl or 4-methoxyphenylhydrazine hydrochloride provided 5-cyano-3-(2,5-dimethylindol-3-yl)-1,2,4-thiadiazole (2) or 5-cyano-3-(5-methoxy-2-methylindol-3-yl)-1,2,4-thiadiazole (3) as the sole product, respectively. In contrast, treatment of 1 with phenylhydrazine hydrochloride resulted in the formation of 5-cyano-3-(2-methylindol-3-y...

THE SYNTHESIS OF SIX THIADIAZOLE NUCLEOSIDE ANALOGS IS REPORTED 5-diacetylamino-1,2,4-thiadiazol-3-one (1), 5-amino-2- (tetrahydrofuran-2-yl)-1,2,4-thiadiazol-3-one (2), 5-amino-3-[(2'-hydroxyethoxy)methyl]-1,3,4-thiadiazol-2-one (3), 5-amino-3-(4'-hydroxy-2'-hydroxymethyl-butyl)-1,3,4-thiadiazole-2-thione (4), (R)-5-amino-3-(2',3'-dihydroxypropyl)-1,3,4-thiadiazole-2-thione (5), and (S)-5-amin...

A new series of aromatic and heterocyclic sulfonamides, including six new derivatives, 2-(3-cyclohexene-1-carbamido)-1,3,4-thiadiazole-5-sulfonamide (CCTS), 4-(3-cyclohexene-1-carbamido) methyl-benzenesulfonamide (CCBS), 2-(9-octadecenoylamido)-1,3,4-thiadiazole-5-sulfonamide (ODTS), 2-(4,7,10-trioxa-tetradecanoylamido)-1,3,4-thiadiazole-5-sulfonamide (TDTS), 2-(coumarine-3-carbamido)-1,3,4-thi...

Thiirene, Thioketene, 1,2,3-Thiadiazole, Thio-Wolff Rearrangement Photolysis of argon-matrix isolated 4,5-bis(carbomethoxy)-l,2,3-thiadiazole with A = 254 or 265 nm resulted in the almost quantitative formation of bis(carbomethoxy)thiirene (3g). Photolysis of 3g could only be carried out by long irradiation times at short wavelength A = 210nm and resulted mainly in extensive fragmentation inste...

]'he thiadiazole derivatives ~-amino-l,S-4-thiadiazole and 5~-ethylamino-l,gAthiadiazole retarded the growth of leukemia LI~10 and extended the survival time of the mice. The thiadiazoles were approximately as effective as the folie acid antagonist aminopterin but considerably less effective than amethopterin in inereasing the life span of the leukemic mice. The antileukemie action and host tox...

A series of 5-substituted-2-phenyl-1, 3, 4-thiadiazole were prepared by the reaction of different substituted benzoylisothiocyanate with 5-amino -2-phenyl -1, 3, 4-thiadiazole. The target molecules were characterized by CHNS analysis, IR, NMR and mass spectra. All these new compounds were screened for antibacterial and antifungal activity. Some of those compounds had promising antimicrobial act...

A new series of thiadiazole-enaminones 4 were synthesized via reactions of 5-acetyl-1,3,4-thiadiazoles 3 with dimethylformamide-dimethylacetal (DMF-DMA). The simple phenyl substituted thiadiazole-enaminone 4f was used as a synthetic precursor for the preparation of a wide variety of new heterocyclic compounds, including the 5-substituted-1,3,4-thiadiazole derivatives 5, 6, 11, 12 and 13, which ...

Dibromoderivatives of benzofused chalcogen-nitrogen heterocycles are important precursors in the synthesis various photovoltaic materials. 4,7-Dibromobenzo[d][1,2,3]thiadiazole is a practically unexplored compound this series. In communication, it was shown that nucleophilic substitution 4,7-dibromobenzo[d][1,2,3]thiadiazole with morpholine gave selectively 4-substituted product—4-(7-bromobenzo...

Molecules of 2-amino-5-trifluoromethyl-1,3,4-thiadiazole, C3H2F3N3S, are linked by two independent N-H...N hydrogen bonds into sheets of alternating R(2)(2)(8) and R(6)(6)(20) rings, while the molecules of the unsubstituted 2-amino-1,3,4-thiadiazole, C2H3N3S, are linked, again by two independent N-H...N hydrogen bonds, but into chains of edge-fused R(2)(2)(8) and R(4)(4)(10) rings.

Electron-withdrawing heterocyclic units are found in most organic optoelectronic materials. Benzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole) is an interesting new system, the chemical properties of which much less studied than other fused thiadiazoles. Cyano derivatives electron-accepting heterocycles known as potential components photoluminescent In this communication, benzo[1,2-d:4,5-d′]bis([1,2,3]...