An improved synthesis of 3-hydroxy-4-pyridone via an Elbs oxidation of 4-pyridone and isolation of 4-pyridone-3-sulfate is described.

In previous experiments reported from this laboratory (1) N-methyl-4-pyridone-5-carboxamide was isolated from rat urine and identified as the major urinary metabolite of the pyridine nucleotides. Recently Wieland et al. (2) synthesized this 4-pyridone and have found their synthetic product to be identical with the compound isolated from rat urine. Experiments have now been carried out to determ...

The aldehyde oxidases from rabbit and hog livers have been purified to homogeneity by modifications of and additions to previously published procedures. The final preparations were judged to be homogeneous on the basis of ultracentrifugal, electrophoretic, chromatographic, spectral, and kinetic criteria. A number of physical and kinetic properties of the homogeneous enzymes have been determined...

In the title complex, [Ag(NO(3))(C(5)H(5)NO)](n), the Ag(I) atom is coordinated by two O atoms from two different 4-pyridone ligands and two O atoms from one nitrate anion, displaying a nearly planar coordination geometry. The O atoms of two 4-pyridone ligands bridge two symmetrically related AgNO(3) units, forming a dimer, with an Ag⋯Ag separation of 3.680 (2) Å. Neighbouring dimers are linked...

Rhodium(I)-complexes catalyzed the 1,4-conjugate addition of arylzinc chlorides to N-Boc-4-pyridone in the presence of chlorotrimethylsilane (TMSCl). A combination of [RhCl(C₂H₄)₂]₂ and BINAP was determined to be the most effective catalyst to promote the 1,4-conjugate addition reactions of arylzinc chlorides to N-Boc-4-pyridone. A broad scope of arylzinc reagents with both electron-withdrawing...

6,7-Diethoxy-1-[1-(2-methoxyethyl)-2-oxo-1,2-dihydropyridin- 4-yl]naphthalene-2,3-dimethanol [T-440, (1)] is a potential anti-asthmatic agent based on selective phosphodiesterase 4 inhibition. It was necessary for the further evaluation of 1 to develop an efficient synthetic route for 1, especially the construction of the 1-(2-methoxyethyl)-2-pyridone moiety. We examined an N-selective alkylati...

A new class of thermotropic lanthanidomesogens has been designed and prepared. They are based on 4-pyridone ligands that possess mesogenic cyanobiphenyl groups attached to the 4-pyridone unit via a flexible long alkyl spacer and show a very high thermal stability (decomposition temperatures near 300 °C). Depending on the alkyl length spacer, these complexes exhibit a SmA phase with transition t...