Kelley, David E., F. Leland Thaete, Fred Troost, Trina Huwe, and Bret H. Goodpaster. Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance. Am J Physiol Endocrinol Metab 278: E941–E948, 2000.—Whereas truncal (central) adiposity is strongly associated with the insulin resistant metabolic syndrome, it is uncertain whether this is accounted for principally by visceral adipos...

Benthem, Lambertus, Thomas O. Mundinger, and Gerald J. Taborsky, Jr. Meal-induced insulin secretion in dogs is mediated by both branches of the autonomic nervous system. Am J Physiol Endocrinol Metab 278: E603–E610, 2000.—We investigated the relationship between autonomic activity to the pancreas and insulin secretion in chronically catheterized dogs when food was shown, during eating, and duri...

Martı́n, Martı́n G., Jiafang Wang, R. Sergio SolorzanoVargas, Jason T. Lam, Eric Turk, and Ernest M. Wright. Regulation of the human Na1-glucose cotransporter gene, SGLT1, by HNF-1 and Sp1. Am J Physiol Gastrointest Liver Physiol 278: G591–G603, 2000.—The Na1-glucose cotransporter (SGLT1) is expressed primarily by small intestinal epithelial cells and transports the monosaccharides glucose and ga...

41 REASONS FOR DEMAND MANAGEMENT IN THE NETHERLANDS Despite the already overcrowded roads, especially in and around the Dutch conurbation, a further growth in the use of cars is expected in the near and farther future. Demographic and economic forces are the main factors for this development. There is widespread consensus, not only in The Netherlands, that building roads is not the right answer...

Green, H., R. Tupling, B. Roy, D. O’Toole, M. Burnett, and S. Grant. Adaptations in skeletal muscle exercise metabolism to a sustained session of heavy intermittent exercise. Am. J. Physiol. Endocrinol. Metab. 278: E118–E126, 2000.—The purpose of this study was to investigate the hypothesis that a single, extended session of heavy exercise would be effective in inducing adaptations in energy me...

Cortright, Ronald N., John L. Azevedo, Jr., Qian Zhou, Madhur Sinha, Walter J. Pories, Samar I. Itani, and G. Lynis Dohm. Protein kinase C modulates insulin action in human skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 278: E553–E562, 2000.—There is good evidence from cell lines and rodents that elevated protein kinase C (PKC) overexpression/activity causes insulin resistance. Therefore, ...

Watson, Alastair J. M., and D. Mark Pritchard. Lessons from Genetically Engineered Animal Models. VII. Apoptosis in intestinal epithelium: lessons from transgenic and knockout mice. Am. J. Physiol. Gastrointest. Liver Physiol. 278: G1–G5, 2000.—Apoptosis plays an important role in homeostasis of intestinal epithelia and is also a stress response to toxic stimuli. Transgenic and knockout mice ha...

MicroRNAs (miRNA) are short endogenous noncoding RNA molecules that regulate fundamental cellular processes such as cell differentiation, cell proliferation and apoptosis through modulation of gene expression. Critical to understanding the role of miRNAs in this regulation is a method to rapidly and accurately quantitate miRNA gene expression. Existing methods lack sensitivity, specificity and ...